Incidence and severity of crucial late effects after allogeneic HSCT for malignancy under the age of 3 years

TBI is what really matters

D. Bresters, A. Lawitschka, Chiara Cugno, U. Pötschger, A. Dalissier, G. Michel, K. Vettenranta, M. Sundin, A. Al-Seraihy, M. Faraci, P. Sedlacek, A. B. Versluys, A. Jenkins, P. Lutz, B. Gibson, A. Leiper, M. A. Diaz, P. J. Shaw, R. Skinner, T. A. O'Brien & 3 others N. Salooja, P. Bader, C. Peters

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Younger children are considered to be more vulnerable to late effects (LE), which prompted us to study LE in patients after haematopoietic stem cell transplantation (HSCT) for a haematological malignancy before the age of 3. In this multicentre EBMT study, cumulative incidence (CI) and severity of endocrine LE, central nervous system complications and secondary malignancies at 5, 10, 15 and 20 years of follow-up were assessed. Risk factors (RF) like gender, diagnosis, age at and year of HSCT, TBI- or chemo-conditioning and GVHD were analysed. CI of any LE was 0.30, 0.52, 0.66 and 0.72 at 5, 10, 15 and 20 years after HSCT, respectively. In 25% of the patients, LE were severe at a median follow-up of 10.4 years. In multivariate analysis, only TBI was a RF for having any LE and for thyroid dysfunction and growth disturbance. Female gender was a RF for delayed pubertal development. Some more insight could be gained by descriptive analysis regarding the role of TBI and GVHD on the severity of LE. Although only five selected LE have been studied and median follow-up is relatively short, the incidence and severity of these LE are considerable but not different from what has been found in older children and TBI is the main RF.

Original languageEnglish
Pages (from-to)1482-1489
Number of pages8
JournalBone Marrow Transplantation
Volume51
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

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Hematopoietic Stem Cell Transplantation
Incidence
Neoplasms
Hematologic Neoplasms
Multicenter Studies
Thyroid Gland
Multivariate Analysis
Central Nervous System
Growth

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Incidence and severity of crucial late effects after allogeneic HSCT for malignancy under the age of 3 years : TBI is what really matters. / Bresters, D.; Lawitschka, A.; Cugno, Chiara; Pötschger, U.; Dalissier, A.; Michel, G.; Vettenranta, K.; Sundin, M.; Al-Seraihy, A.; Faraci, M.; Sedlacek, P.; Versluys, A. B.; Jenkins, A.; Lutz, P.; Gibson, B.; Leiper, A.; Diaz, M. A.; Shaw, P. J.; Skinner, R.; O'Brien, T. A.; Salooja, N.; Bader, P.; Peters, C.

In: Bone Marrow Transplantation, Vol. 51, No. 11, 01.11.2016, p. 1482-1489.

Research output: Contribution to journalArticle

Bresters, D, Lawitschka, A, Cugno, C, Pötschger, U, Dalissier, A, Michel, G, Vettenranta, K, Sundin, M, Al-Seraihy, A, Faraci, M, Sedlacek, P, Versluys, AB, Jenkins, A, Lutz, P, Gibson, B, Leiper, A, Diaz, MA, Shaw, PJ, Skinner, R, O'Brien, TA, Salooja, N, Bader, P & Peters, C 2016, 'Incidence and severity of crucial late effects after allogeneic HSCT for malignancy under the age of 3 years: TBI is what really matters', Bone Marrow Transplantation, vol. 51, no. 11, pp. 1482-1489. https://doi.org/10.1038/bmt.2016.139
Bresters, D. ; Lawitschka, A. ; Cugno, Chiara ; Pötschger, U. ; Dalissier, A. ; Michel, G. ; Vettenranta, K. ; Sundin, M. ; Al-Seraihy, A. ; Faraci, M. ; Sedlacek, P. ; Versluys, A. B. ; Jenkins, A. ; Lutz, P. ; Gibson, B. ; Leiper, A. ; Diaz, M. A. ; Shaw, P. J. ; Skinner, R. ; O'Brien, T. A. ; Salooja, N. ; Bader, P. ; Peters, C. / Incidence and severity of crucial late effects after allogeneic HSCT for malignancy under the age of 3 years : TBI is what really matters. In: Bone Marrow Transplantation. 2016 ; Vol. 51, No. 11. pp. 1482-1489.
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AU - Cugno, Chiara

AU - Pötschger, U.

AU - Dalissier, A.

AU - Michel, G.

AU - Vettenranta, K.

AU - Sundin, M.

AU - Al-Seraihy, A.

AU - Faraci, M.

AU - Sedlacek, P.

AU - Versluys, A. B.

AU - Jenkins, A.

AU - Lutz, P.

AU - Gibson, B.

AU - Leiper, A.

AU - Diaz, M. A.

AU - Shaw, P. J.

AU - Skinner, R.

AU - O'Brien, T. A.

AU - Salooja, N.

AU - Bader, P.

AU - Peters, C.

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