Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene

L. Osborne, G. Santis, M. Schwarz, K. Klinger, T. Dörk, I. McIntosh, M. Schwartz, V. Nunes, M. Macek, J. Reiss, W. E. Highsmith, R. McMahon, G. Novelli, N. Malik, J. Bürger, M. Anvret, A. Wallace, C. Williams, C. Mathew, R. Rozen & 36 others C. Graham, P. Gasparini, J. Bal, J. J. Cassiman, A. Balassopoulou, L. Davidow, S. Raskin, L. Kalaydjieva, B. Kerem, S. Richards, B. Simon-Bouy, M. Super, U. Wulbrand, M. Keston, Xavier P. Estivill, V. Vavrova, K. J. Friedman, D. Barton, B. Dallapiccola, M. Stuhrmann, F. Beards, A. J M Hill, P. F. Pignatti, H. Cuppens, D. Angelicheva, B. Tümmler, D. J H Brock, T. Casals, M. Macek, J. Schmidtke, A. C. Magee, A. Bonizzato, C. De Boeck, A. Kuffardjieva, M. Hodson, R. A. Knight

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The N1303K mutation was identified in the second nucleotide binding fold of the cystic fibrosis (CF) gene last year. We have gathered data from laboratories throughout Europe and the United States of America in order to estimate its frequency and to attempt to characterise the clinical manifestations of this mutation. N1303K, identified on 216 of nearly 15000 CF chromosomes tested, accounts for 1.5% of all CF chromosomes. The frequency of the N1303K allele varies significantly between countries and ethnic groups, being more common in Southern than in Northern Europe. This variation is independent of the AF508 allele. It was not found on UK Asian, American Black or Australian chromosomes. N1303K is associated with four different linked marker haplotypes for the polymorphic markers XV-2c, KM.19 and pMP6d-9. Ten patients are homozygous for this mutation, whereas 106 of the remainder carry one of 12 known CF mutations in the other CF allele. We classify N1303K as a "severe" mutation with respect to the pancreas, but can find no correlation between this mutation, in either the homozygous or heterozygous state, and the severity of lung disease.

Original languageEnglish
Pages (from-to)653-658
Number of pages6
JournalHuman Genetics
Volume89
Issue number6
DOIs
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Cystic Fibrosis
Mutation
Incidence
Genes
Chromosomes
Alleles
Asian Americans
Ethnic Groups
Gene Frequency
Haplotypes
Lung Diseases
Pancreas
Nucleotides

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Osborne, L., Santis, G., Schwarz, M., Klinger, K., Dörk, T., McIntosh, I., ... Knight, R. A. (2004). Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene. Human Genetics, 89(6), 653-658. https://doi.org/10.1007/BF00221957

Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene. / Osborne, L.; Santis, G.; Schwarz, M.; Klinger, K.; Dörk, T.; McIntosh, I.; Schwartz, M.; Nunes, V.; Macek, M.; Reiss, J.; Highsmith, W. E.; McMahon, R.; Novelli, G.; Malik, N.; Bürger, J.; Anvret, M.; Wallace, A.; Williams, C.; Mathew, C.; Rozen, R.; Graham, C.; Gasparini, P.; Bal, J.; Cassiman, J. J.; Balassopoulou, A.; Davidow, L.; Raskin, S.; Kalaydjieva, L.; Kerem, B.; Richards, S.; Simon-Bouy, B.; Super, M.; Wulbrand, U.; Keston, M.; Estivill, Xavier P.; Vavrova, V.; Friedman, K. J.; Barton, D.; Dallapiccola, B.; Stuhrmann, M.; Beards, F.; Hill, A. J M; Pignatti, P. F.; Cuppens, H.; Angelicheva, D.; Tümmler, B.; Brock, D. J H; Casals, T.; Macek, M.; Schmidtke, J.; Magee, A. C.; Bonizzato, A.; De Boeck, C.; Kuffardjieva, A.; Hodson, M.; Knight, R. A.

In: Human Genetics, Vol. 89, No. 6, 2004, p. 653-658.

Research output: Contribution to journalArticle

Osborne, L, Santis, G, Schwarz, M, Klinger, K, Dörk, T, McIntosh, I, Schwartz, M, Nunes, V, Macek, M, Reiss, J, Highsmith, WE, McMahon, R, Novelli, G, Malik, N, Bürger, J, Anvret, M, Wallace, A, Williams, C, Mathew, C, Rozen, R, Graham, C, Gasparini, P, Bal, J, Cassiman, JJ, Balassopoulou, A, Davidow, L, Raskin, S, Kalaydjieva, L, Kerem, B, Richards, S, Simon-Bouy, B, Super, M, Wulbrand, U, Keston, M, Estivill, XP, Vavrova, V, Friedman, KJ, Barton, D, Dallapiccola, B, Stuhrmann, M, Beards, F, Hill, AJM, Pignatti, PF, Cuppens, H, Angelicheva, D, Tümmler, B, Brock, DJH, Casals, T, Macek, M, Schmidtke, J, Magee, AC, Bonizzato, A, De Boeck, C, Kuffardjieva, A, Hodson, M & Knight, RA 2004, 'Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene', Human Genetics, vol. 89, no. 6, pp. 653-658. https://doi.org/10.1007/BF00221957
Osborne L, Santis G, Schwarz M, Klinger K, Dörk T, McIntosh I et al. Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene. Human Genetics. 2004;89(6):653-658. https://doi.org/10.1007/BF00221957
Osborne, L. ; Santis, G. ; Schwarz, M. ; Klinger, K. ; Dörk, T. ; McIntosh, I. ; Schwartz, M. ; Nunes, V. ; Macek, M. ; Reiss, J. ; Highsmith, W. E. ; McMahon, R. ; Novelli, G. ; Malik, N. ; Bürger, J. ; Anvret, M. ; Wallace, A. ; Williams, C. ; Mathew, C. ; Rozen, R. ; Graham, C. ; Gasparini, P. ; Bal, J. ; Cassiman, J. J. ; Balassopoulou, A. ; Davidow, L. ; Raskin, S. ; Kalaydjieva, L. ; Kerem, B. ; Richards, S. ; Simon-Bouy, B. ; Super, M. ; Wulbrand, U. ; Keston, M. ; Estivill, Xavier P. ; Vavrova, V. ; Friedman, K. J. ; Barton, D. ; Dallapiccola, B. ; Stuhrmann, M. ; Beards, F. ; Hill, A. J M ; Pignatti, P. F. ; Cuppens, H. ; Angelicheva, D. ; Tümmler, B. ; Brock, D. J H ; Casals, T. ; Macek, M. ; Schmidtke, J. ; Magee, A. C. ; Bonizzato, A. ; De Boeck, C. ; Kuffardjieva, A. ; Hodson, M. ; Knight, R. A. / Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene. In: Human Genetics. 2004 ; Vol. 89, No. 6. pp. 653-658.
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abstract = "The N1303K mutation was identified in the second nucleotide binding fold of the cystic fibrosis (CF) gene last year. We have gathered data from laboratories throughout Europe and the United States of America in order to estimate its frequency and to attempt to characterise the clinical manifestations of this mutation. N1303K, identified on 216 of nearly 15000 CF chromosomes tested, accounts for 1.5{\%} of all CF chromosomes. The frequency of the N1303K allele varies significantly between countries and ethnic groups, being more common in Southern than in Northern Europe. This variation is independent of the AF508 allele. It was not found on UK Asian, American Black or Australian chromosomes. N1303K is associated with four different linked marker haplotypes for the polymorphic markers XV-2c, KM.19 and pMP6d-9. Ten patients are homozygous for this mutation, whereas 106 of the remainder carry one of 12 known CF mutations in the other CF allele. We classify N1303K as a {"}severe{"} mutation with respect to the pancreas, but can find no correlation between this mutation, in either the homozygous or heterozygous state, and the severity of lung disease.",
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T1 - Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene

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AU - Santis, G.

AU - Schwarz, M.

AU - Klinger, K.

AU - Dörk, T.

AU - McIntosh, I.

AU - Schwartz, M.

AU - Nunes, V.

AU - Macek, M.

AU - Reiss, J.

AU - Highsmith, W. E.

AU - McMahon, R.

AU - Novelli, G.

AU - Malik, N.

AU - Bürger, J.

AU - Anvret, M.

AU - Wallace, A.

AU - Williams, C.

AU - Mathew, C.

AU - Rozen, R.

AU - Graham, C.

AU - Gasparini, P.

AU - Bal, J.

AU - Cassiman, J. J.

AU - Balassopoulou, A.

AU - Davidow, L.

AU - Raskin, S.

AU - Kalaydjieva, L.

AU - Kerem, B.

AU - Richards, S.

AU - Simon-Bouy, B.

AU - Super, M.

AU - Wulbrand, U.

AU - Keston, M.

AU - Estivill, Xavier P.

AU - Vavrova, V.

AU - Friedman, K. J.

AU - Barton, D.

AU - Dallapiccola, B.

AU - Stuhrmann, M.

AU - Beards, F.

AU - Hill, A. J M

AU - Pignatti, P. F.

AU - Cuppens, H.

AU - Angelicheva, D.

AU - Tümmler, B.

AU - Brock, D. J H

AU - Casals, T.

AU - Macek, M.

AU - Schmidtke, J.

AU - Magee, A. C.

AU - Bonizzato, A.

AU - De Boeck, C.

AU - Kuffardjieva, A.

AU - Hodson, M.

AU - Knight, R. A.

PY - 2004

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N2 - The N1303K mutation was identified in the second nucleotide binding fold of the cystic fibrosis (CF) gene last year. We have gathered data from laboratories throughout Europe and the United States of America in order to estimate its frequency and to attempt to characterise the clinical manifestations of this mutation. N1303K, identified on 216 of nearly 15000 CF chromosomes tested, accounts for 1.5% of all CF chromosomes. The frequency of the N1303K allele varies significantly between countries and ethnic groups, being more common in Southern than in Northern Europe. This variation is independent of the AF508 allele. It was not found on UK Asian, American Black or Australian chromosomes. N1303K is associated with four different linked marker haplotypes for the polymorphic markers XV-2c, KM.19 and pMP6d-9. Ten patients are homozygous for this mutation, whereas 106 of the remainder carry one of 12 known CF mutations in the other CF allele. We classify N1303K as a "severe" mutation with respect to the pancreas, but can find no correlation between this mutation, in either the homozygous or heterozygous state, and the severity of lung disease.

AB - The N1303K mutation was identified in the second nucleotide binding fold of the cystic fibrosis (CF) gene last year. We have gathered data from laboratories throughout Europe and the United States of America in order to estimate its frequency and to attempt to characterise the clinical manifestations of this mutation. N1303K, identified on 216 of nearly 15000 CF chromosomes tested, accounts for 1.5% of all CF chromosomes. The frequency of the N1303K allele varies significantly between countries and ethnic groups, being more common in Southern than in Northern Europe. This variation is independent of the AF508 allele. It was not found on UK Asian, American Black or Australian chromosomes. N1303K is associated with four different linked marker haplotypes for the polymorphic markers XV-2c, KM.19 and pMP6d-9. Ten patients are homozygous for this mutation, whereas 106 of the remainder carry one of 12 known CF mutations in the other CF allele. We classify N1303K as a "severe" mutation with respect to the pancreas, but can find no correlation between this mutation, in either the homozygous or heterozygous state, and the severity of lung disease.

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