In Situ Nanoliter-Scale Polymer Fabrication for Flexible Cell Patterning

Albert R. Liberski, Rong Zhang, Mark Bradley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Drug-testing technologies, biosensor fabrication, tissue engineering, and basic biological research depend strongly on the patterning of live animal cells. Current techniques for controlling cellular adhesion are restricted with two primary limitations. Firstly, the complexity of the available patterns is very limited and, secondly, the pallet of materials that induce cellular patterning is exhaustible. Here, we demonstrate a method for computer-aided control of cell patterning using a scientific inkjet printer that yields a highly complex cellular pattern suitable for applications in regenerative medicine and rapid prototyping, and a strategy for using in situ polymerization for fabrication polymeric patterns directly on-chip.

Original languageEnglish
Pages (from-to)285-293
Number of pages9
JournalJALA - Journal of the Association for Laboratory Automation
Volume14
Issue number5
DOIs
Publication statusPublished - 1 Oct 2009
Externally publishedYes

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Keywords

  • biomaterials
  • cell patterning
  • mES cells
  • nL scale-in situ polymerization
  • software for inkjet printing
  • synthetic cell binders

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Computer Science Applications

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