In Silico dynamic molecular interaction networks for the discovery of new therapeutic targets

Todor Vujasinovic, André Sinisa Zampera, Pascale Jackers, Despina Sanoudou, Antoine Depaulis

    Research output: Contribution to journalReview article

    3 Citations (Scopus)

    Abstract

    Systems biology has emerged as a major trend in biological research during the past decade. As living organisms are described in more and more detail, it aims at filling the gap between understanding basic molecular processes and complex biological systems in which new properties often emerge from the combination of these elementary processes. This approach culminates in the development of computer-based mathematical models of physiological and pathophysiological processes. We review the state of the art in dynamic modelling, with emphasis on two complementary approaches: the modelling of small systems that is mostly developed by academic teams and aims at understanding generic biological properties, and the modelling of large systems that is mostly implemented by industrial companies and aims at the generation of new therapeutic strategies. We also provide an example of such large-scale modelling applied to the identification of drug targets for neurodegeneration.

    Original languageEnglish
    Pages (from-to)2241-2251
    Number of pages11
    JournalCurrent Pharmaceutical Design
    Volume16
    Issue number20
    DOIs
    Publication statusPublished - 20 Aug 2010

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    Keywords

    • Bioinformatics
    • Data mining
    • Models
    • Proteomics
    • Systems biology
    • Transcriptomics

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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