In Silico dynamic molecular interaction networks for the discovery of new therapeutic targets

Todor Vujasinovic, André Sinisa Zampera, Pascale Jackers, Despina Sanoudou, Antoine Depaulis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Systems biology has emerged as a major trend in biological research during the past decade. As living organisms are described in more and more detail, it aims at filling the gap between understanding basic molecular processes and complex biological systems in which new properties often emerge from the combination of these elementary processes. This approach culminates in the development of computer-based mathematical models of physiological and pathophysiological processes. We review the state of the art in dynamic modelling, with emphasis on two complementary approaches: the modelling of small systems that is mostly developed by academic teams and aims at understanding generic biological properties, and the modelling of large systems that is mostly implemented by industrial companies and aims at the generation of new therapeutic strategies. We also provide an example of such large-scale modelling applied to the identification of drug targets for neurodegeneration.

Original languageEnglish
Pages (from-to)2241-2251
Number of pages11
JournalCurrent Pharmaceutical Design
Volume16
Issue number20
DOIs
Publication statusPublished - 20 Aug 2010
Externally publishedYes

Fingerprint

Physiological Phenomena
Biological Phenomena
Systems Biology
Molecular Dynamics Simulation
Computer Simulation
Theoretical Models
Research
Pharmaceutical Preparations
Therapeutics

Keywords

  • Bioinformatics
  • Data mining
  • Models
  • Proteomics
  • Systems biology
  • Transcriptomics

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

In Silico dynamic molecular interaction networks for the discovery of new therapeutic targets. / Vujasinovic, Todor; Zampera, André Sinisa; Jackers, Pascale; Sanoudou, Despina; Depaulis, Antoine.

In: Current Pharmaceutical Design, Vol. 16, No. 20, 20.08.2010, p. 2241-2251.

Research output: Contribution to journalArticle

Vujasinovic, T, Zampera, AS, Jackers, P, Sanoudou, D & Depaulis, A 2010, 'In Silico dynamic molecular interaction networks for the discovery of new therapeutic targets', Current Pharmaceutical Design, vol. 16, no. 20, pp. 2241-2251. https://doi.org/10.2174/138161210791792822
Vujasinovic, Todor ; Zampera, André Sinisa ; Jackers, Pascale ; Sanoudou, Despina ; Depaulis, Antoine. / In Silico dynamic molecular interaction networks for the discovery of new therapeutic targets. In: Current Pharmaceutical Design. 2010 ; Vol. 16, No. 20. pp. 2241-2251.
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