Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation

Uazman Alam, Asher Fawwad, Fariha Shaheen, Bilal Tahir, Abdul Basit, Rayaz Malik

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective. To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy. Methods. This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks. Results. Of 143 participants, 41.3% were vitamin D deficient (vitamin D < 20 ng/ml). Treatment with vitamin D resulted in a significant increase in 25(OH)D (P<0.0001) and a significant improvement in the NeuroQoL subscale score for emotional distress (P=0.04), with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of "quite a lot" (P<0.05) and "very much" (P<0.0001) with a significant reduction in the baseline response of having a "poor" QoL from 5.2% to 0.7% (P<0.0001) and an increase in the response of an "excellent QoL" from 1.5% to 7.4% (P<0.0001). Conclusion. Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.

Original languageEnglish
Article number7928083
JournalJournal of Diabetes Research
Volume2017
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Vitamin D
Quality of Life
Diabetic Neuropathies
Paresthesia
Touch
Foot
Temperature

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation. / Alam, Uazman; Fawwad, Asher; Shaheen, Fariha; Tahir, Bilal; Basit, Abdul; Malik, Rayaz.

In: Journal of Diabetes Research, Vol. 2017, 7928083, 01.01.2017.

Research output: Contribution to journalArticle

Alam, Uazman ; Fawwad, Asher ; Shaheen, Fariha ; Tahir, Bilal ; Basit, Abdul ; Malik, Rayaz. / Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation. In: Journal of Diabetes Research. 2017 ; Vol. 2017.
@article{d78f4c2df9824c458888e9a5e45cbcf7,
title = "Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation",
abstract = "Objective. To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy. Methods. This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks. Results. Of 143 participants, 41.3{\%} were vitamin D deficient (vitamin D < 20 ng/ml). Treatment with vitamin D resulted in a significant increase in 25(OH)D (P<0.0001) and a significant improvement in the NeuroQoL subscale score for emotional distress (P=0.04), with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of {"}quite a lot{"} (P<0.05) and {"}very much{"} (P<0.0001) with a significant reduction in the baseline response of having a {"}poor{"} QoL from 5.2{\%} to 0.7{\%} (P<0.0001) and an increase in the response of an {"}excellent QoL{"} from 1.5{\%} to 7.4{\%} (P<0.0001). Conclusion. Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.",
author = "Uazman Alam and Asher Fawwad and Fariha Shaheen and Bilal Tahir and Abdul Basit and Rayaz Malik",
year = "2017",
month = "1",
day = "1",
doi = "10.1155/2017/7928083",
language = "English",
volume = "2017",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation

AU - Alam, Uazman

AU - Fawwad, Asher

AU - Shaheen, Fariha

AU - Tahir, Bilal

AU - Basit, Abdul

AU - Malik, Rayaz

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective. To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy. Methods. This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks. Results. Of 143 participants, 41.3% were vitamin D deficient (vitamin D < 20 ng/ml). Treatment with vitamin D resulted in a significant increase in 25(OH)D (P<0.0001) and a significant improvement in the NeuroQoL subscale score for emotional distress (P=0.04), with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of "quite a lot" (P<0.05) and "very much" (P<0.0001) with a significant reduction in the baseline response of having a "poor" QoL from 5.2% to 0.7% (P<0.0001) and an increase in the response of an "excellent QoL" from 1.5% to 7.4% (P<0.0001). Conclusion. Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.

AB - Objective. To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy. Methods. This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks. Results. Of 143 participants, 41.3% were vitamin D deficient (vitamin D < 20 ng/ml). Treatment with vitamin D resulted in a significant increase in 25(OH)D (P<0.0001) and a significant improvement in the NeuroQoL subscale score for emotional distress (P=0.04), with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of "quite a lot" (P<0.05) and "very much" (P<0.0001) with a significant reduction in the baseline response of having a "poor" QoL from 5.2% to 0.7% (P<0.0001) and an increase in the response of an "excellent QoL" from 1.5% to 7.4% (P<0.0001). Conclusion. Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.

UR - http://www.scopus.com/inward/record.url?scp=85042509489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042509489&partnerID=8YFLogxK

U2 - 10.1155/2017/7928083

DO - 10.1155/2017/7928083

M3 - Article

VL - 2017

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 7928083

ER -