Improved T1-weighted dynamic contrast-enhanced MRI to probe microvascularity and heterogeneity of human glioma

Mohan Pauliah, Vipin Saxena, Mohammad Haris, Nuzhat Husain, Ram Kishore S Rathore, Rakesh K. Gupta

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Dynamic contrast-enhanced (DCE) T1-weighted magnetic resonance imaging (MRI) is a powerful tool capable of providing quantitative assessment of contrast uptake and characterization of microvascular structure in human gliomas. The kinetics of the bolus injection doped with increasing concentrations of gadopentate dimeglumine (Gd-DTPA) depends on tissue as well as pulse sequence parameters. A simple method is described that overcomes the limitation of relative signal increase measurement and may lead to improved accuracy in quantification of perfusion indices of glioma. Based on an analysis of the contrast behavior of spoiled gradient-recalled echo sequence; a parameter K with arbitrary unit 5.0 is introduced, which provides a better approximation to the differential T1 relaxation rate. DCE-MRI measurements of relative cerebral blood volume (rCBV) and cerebral blood flow (rCBF) were calculated in 25 patients with brain tumors (15=high-grade glioma, 10=low-grade glioma). The mean rCBV was 6.46±2.45 in high-grade glioma and 2.89±1.47 in the low-grade glioma. The rCBF was 3.94±1.47 in high-grade glioma while 2.25±0.87 in low-grade glioma. A significant difference in rCBF and rCBV was found between high- and low-grade gliomas. This simple and robust technique reveals the complexity of tumor vasculature and heterogeneity that may aid in therapeutic management especially in nonenhancing high-grade gliomas. We conclude that the precontrast medium steady-state residue parameter K may be useful in improved quantification of perfusion indices in human glioma using T1-weighted DCE-MRI.

Original languageEnglish
Pages (from-to)1292-1299
Number of pages8
JournalMagnetic Resonance Imaging
Volume25
Issue number9
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

Fingerprint

Magnetic resonance
Glioma
magnetic resonance
grade
Blood
Magnetic Resonance Imaging
Imaging techniques
probes
Cerebrovascular Circulation
blood volume
blood flow
Tumors
Gadolinium DTPA
tumors
signal measurement
Perfusion
Brain
Tissue
Kinetics
brain

Keywords

  • Algorithm
  • Dynamic contrast enhancement
  • Relative cerebral blood volume
  • T-weighted imaging
  • Tumor heterogeneity

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Improved T1-weighted dynamic contrast-enhanced MRI to probe microvascularity and heterogeneity of human glioma. / Pauliah, Mohan; Saxena, Vipin; Haris, Mohammad; Husain, Nuzhat; Rathore, Ram Kishore S; Gupta, Rakesh K.

In: Magnetic Resonance Imaging, Vol. 25, No. 9, 11.2007, p. 1292-1299.

Research output: Contribution to journalArticle

Pauliah, Mohan ; Saxena, Vipin ; Haris, Mohammad ; Husain, Nuzhat ; Rathore, Ram Kishore S ; Gupta, Rakesh K. / Improved T1-weighted dynamic contrast-enhanced MRI to probe microvascularity and heterogeneity of human glioma. In: Magnetic Resonance Imaging. 2007 ; Vol. 25, No. 9. pp. 1292-1299.
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