Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGluR4 knockout mice

E. Iscru, H. Goddyn, Tariq Ahmed, Z. Callaerts-Vegh, R. D'Hooge, D. Balschun

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Although much information about metabotropic glutamate receptors (mGluRs) and their role in normal and pathologic brain function has been accumulated during the last decades, the role of group III mGluRs is still scarcely documented. Here, we examined mGluR4 knockout mice for types of behavior and synaptic plasticity that depend on either the hippocampus or the prefrontal cortex (PFC). We found improved spatial short- and long-term memory in the radial arm maze, which was accompanied by enhanced long-term potentiation (LTP) in hippocampal CA1 region. In contrast, LTP in the PFC was unchanged when compared with wild-type controls. Changes in paired-pulse facilitation that became overt in the presence of the GABAA antagonist picrotoxin indicated a function of mGluR4 in maintaining the excitation/inhibition balance, which is of crucial importance for information processing in the brain and the deterioration of these processes in neuropsychological disorders such as autism, epilepsy and schizophrenia.

Original languageEnglish
Pages (from-to)615-625
Number of pages11
JournalGenes, Brain and Behavior
Volume12
Issue number6
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

Fingerprint

Metabotropic Glutamate Receptors
Long-Term Potentiation
Prefrontal Cortex
Knockout Mice
GABA-A Receptor Antagonists
Hippocampal CA1 Region
Picrotoxin
Neuronal Plasticity
Long-Term Memory
Brain
Autistic Disorder
Automatic Data Processing
Epilepsy
Hippocampus
Schizophrenia
Spatial Learning
metabotropic glutamate receptor 4
Inhibition (Psychology)

Keywords

  • CA1 region
  • Dentate gyrus
  • GABA receptors
  • Hippocampus
  • Long-term potentiation
  • Metabotropic glutamate receptors
  • Metaplasticity
  • Prefrontal cortex
  • Spatial learning
  • Synaptic plasticity

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Genetics
  • Neurology

Cite this

Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGluR4 knockout mice. / Iscru, E.; Goddyn, H.; Ahmed, Tariq; Callaerts-Vegh, Z.; D'Hooge, R.; Balschun, D.

In: Genes, Brain and Behavior, Vol. 12, No. 6, 08.2013, p. 615-625.

Research output: Contribution to journalArticle

Iscru, E. ; Goddyn, H. ; Ahmed, Tariq ; Callaerts-Vegh, Z. ; D'Hooge, R. ; Balschun, D. / Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGluR4 knockout mice. In: Genes, Brain and Behavior. 2013 ; Vol. 12, No. 6. pp. 615-625.
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