β-Amyloid protein, the α-synuclein fragment NAC, and protease-resistant forms of prion proteins are found deposited in the pathological lesions associated with neurodegenerative disease. Chemical syntheses of these proteins are notoriously difficult due to aggregation of the peptides on the resin during synthesis. We report optimised solid-phase syntheses of several amyloid peptides in high yield and >90% initial purity.
|Number of pages||8|
|Journal||Protein and Peptide Letters|
|Publication status||Published - 1 Dec 2000|
ASJC Scopus subject areas
- Structural Biology