Improved solid-phase syntheses of amyloid proteins associated with neurodegenerative diseases

Omar M.A. El-Agnaf, Hazel Goodwin, Joseph M. Sheridan, Emma R. Frears, Brian M. Austen

Research output: Contribution to journalArticle

19 Citations (Scopus)


β-Amyloid protein, the α-synuclein fragment NAC, and protease-resistant forms of prion proteins are found deposited in the pathological lesions associated with neurodegenerative disease. Chemical syntheses of these proteins are notoriously difficult due to aggregation of the peptides on the resin during synthesis. We report optimised solid-phase syntheses of several amyloid peptides in high yield and >90% initial purity.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalProtein and Peptide Letters
Issue number1
Publication statusPublished - 1 Dec 2000


ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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