Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin

Vanessa Coremans, Tariq Ahmed, Detlef Balschun, Rudi D'Hooge, Astrid DeVriese, Jonathan Cremer, Flavia Antonucci, Michaël Moons, Veerle Baekelandt, Veerle Reumers, Harold Cremer, Amelia Eisch, Diane Lagace, Tom Janssens, Yuri Bozzi, Matteo Caleo, Edward M. Conway

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Survivin is a unique member of the inhibitor of apoptosis protein (IAP) family in that it exhibits antiapoptotic properties and also promotes the cell cycle and mediates mitosis as a chromosome passenger protein. Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated.Results: To examine the role of neural precursor cell survivin, we first showed that survivin is normally expressed in periventricular neurogenic regions in the embryo, becoming restricted postnatally to proliferating and migrating NPCs in the key neurogenic sites, the subventricular zone (SVZ) and the subgranular zone (SGZ). We then used a conditional gene inactivation strategy to delete the survivin gene prenatally in those neurogenic regions. Lack of embryonic NPC survivin results in viable, fertile mice (SurvivinCamcre) with reduced numbers of SVZ NPCs, absent rostral migratory stream, and olfactory bulb hypoplasia. The phenotype can be partially rescued, as intracerebroventricular gene delivery of survivin during embryonic development increases olfactory bulb neurogenesis, detected postnatally. SurvivinCamcre brains have fewer cortical inhibitory interneurons, contributing to enhanced sensitivity to seizures, and profound deficits in memory and learning.Conclusions: The findings highlight the critical role that survivin plays during neural development, deficiencies of which dramatically impact on postnatal neural function.

Original languageEnglish
Article number2
JournalBMC Neuroscience
Volume11
DOIs
Publication statusPublished - 5 Jan 2010
Externally publishedYes

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Lateral Ventricles
Olfactory Bulb
Neurogenesis
Seizures
Learning
Inhibitor of Apoptosis Proteins
Memory Disorders
Brain
Gene Silencing
Interneurons
Mitosis
Genes
Embryonic Development
Cell Cycle
Embryonic Structures
Chromosomes
Phenotype
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. / Coremans, Vanessa; Ahmed, Tariq; Balschun, Detlef; D'Hooge, Rudi; DeVriese, Astrid; Cremer, Jonathan; Antonucci, Flavia; Moons, Michaël; Baekelandt, Veerle; Reumers, Veerle; Cremer, Harold; Eisch, Amelia; Lagace, Diane; Janssens, Tom; Bozzi, Yuri; Caleo, Matteo; Conway, Edward M.

In: BMC Neuroscience, Vol. 11, 2, 05.01.2010.

Research output: Contribution to journalArticle

Coremans, V, Ahmed, T, Balschun, D, D'Hooge, R, DeVriese, A, Cremer, J, Antonucci, F, Moons, M, Baekelandt, V, Reumers, V, Cremer, H, Eisch, A, Lagace, D, Janssens, T, Bozzi, Y, Caleo, M & Conway, EM 2010, 'Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin', BMC Neuroscience, vol. 11, 2. https://doi.org/10.1186/1471-2202-11-2
Coremans, Vanessa ; Ahmed, Tariq ; Balschun, Detlef ; D'Hooge, Rudi ; DeVriese, Astrid ; Cremer, Jonathan ; Antonucci, Flavia ; Moons, Michaël ; Baekelandt, Veerle ; Reumers, Veerle ; Cremer, Harold ; Eisch, Amelia ; Lagace, Diane ; Janssens, Tom ; Bozzi, Yuri ; Caleo, Matteo ; Conway, Edward M. / Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. In: BMC Neuroscience. 2010 ; Vol. 11.
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AU - Ahmed, Tariq

AU - Balschun, Detlef

AU - D'Hooge, Rudi

AU - DeVriese, Astrid

AU - Cremer, Jonathan

AU - Antonucci, Flavia

AU - Moons, Michaël

AU - Baekelandt, Veerle

AU - Reumers, Veerle

AU - Cremer, Harold

AU - Eisch, Amelia

AU - Lagace, Diane

AU - Janssens, Tom

AU - Bozzi, Yuri

AU - Caleo, Matteo

AU - Conway, Edward M.

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