Impaired lymphocyte function in depressive illness

Ziad Kronfol, Joseph Silva, John Greden, Susan Dembinski, Robert Gardner, Bernard Carroll

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Mood states and immunity may be related. To investigate the immune status of patients with primary depressive illness, we compared in-vitro lymphocytic responses to three different mitogens in 26 drug-free depressed patients and 20 normal controls of comparable age and sex. We observed a generalized and marked decrease in the lymphocyte mitogenic activity among the depressive group. This defect in lymphocyte function may be indicative of an impairment in cell-mediated immunity in patients with primary depressive illness.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalLife Sciences
Volume33
Issue number3
DOIs
Publication statusPublished - 18 Jul 1983
Externally publishedYes

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Lymphocytes
Mitogens
Cellular Immunity
Defects
Immunity
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kronfol, Z., Silva, J., Greden, J., Dembinski, S., Gardner, R., & Carroll, B. (1983). Impaired lymphocyte function in depressive illness. Life Sciences, 33(3), 241-247. https://doi.org/10.1016/0024-3205(83)90382-X

Impaired lymphocyte function in depressive illness. / Kronfol, Ziad; Silva, Joseph; Greden, John; Dembinski, Susan; Gardner, Robert; Carroll, Bernard.

In: Life Sciences, Vol. 33, No. 3, 18.07.1983, p. 241-247.

Research output: Contribution to journalArticle

Kronfol, Z, Silva, J, Greden, J, Dembinski, S, Gardner, R & Carroll, B 1983, 'Impaired lymphocyte function in depressive illness', Life Sciences, vol. 33, no. 3, pp. 241-247. https://doi.org/10.1016/0024-3205(83)90382-X
Kronfol Z, Silva J, Greden J, Dembinski S, Gardner R, Carroll B. Impaired lymphocyte function in depressive illness. Life Sciences. 1983 Jul 18;33(3):241-247. https://doi.org/10.1016/0024-3205(83)90382-X
Kronfol, Ziad ; Silva, Joseph ; Greden, John ; Dembinski, Susan ; Gardner, Robert ; Carroll, Bernard. / Impaired lymphocyte function in depressive illness. In: Life Sciences. 1983 ; Vol. 33, No. 3. pp. 241-247.
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