Impaired lymphocyte function in depressive illness

Ziad Kronfol, Joseph Silva, John Greden, Susan Dembinski, Robert Gardner, Bernard Carroll

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203 Citations (Scopus)

Abstract

Mood states and immunity may be related. To investigate the immune status of patients with primary depressive illness, we compared in-vitro lymphocytic responses to three different mitogens in 26 drug-free depressed patients and 20 normal controls of comparable age and sex. We observed a generalized and marked decrease in the lymphocyte mitogenic activity among the depressive group. This defect in lymphocyte function may be indicative of an impairment in cell-mediated immunity in patients with primary depressive illness.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalLife Sciences
Volume33
Issue number3
DOIs
Publication statusPublished - 18 Jul 1983

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kronfol, Z., Silva, J., Greden, J., Dembinski, S., Gardner, R., & Carroll, B. (1983). Impaired lymphocyte function in depressive illness. Life Sciences, 33(3), 241-247. https://doi.org/10.1016/0024-3205(83)90382-X