Impact of curcumin on sirtuins

A review

Elham Zendedel, Alexandra E. Butler, Stephen Atkin, Amirhossein Sahebkar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Curcumin is a bioactive phytochemical that modulates several physiological and cellular processes leading to therapeutic effects against different diseases. Sirtuins are highly conserved nicotine adenine dinucleotide-dependent proteins that regulate the activity of target enzymes and transcription factors by deacetylation. Curcumin possesses both antioxidant and anti-inflammatory properties and has been shown to increase sirtuin-1 (SIRT1) by activating small molecules. Upregulation of SIRT1 by curcumin has been reported to confer protective effects against a range of neurological disorders including glutamate excitotoxicity, β-amyloid-induced cell death in cortical neurons, cerebral ischemic damage, and stroke. Activation of AMPK and SIRT1 by curcumin has also been noted to mediate the protective effects of curcumin against ischemia/reperfusion injury, cardiac fibrosis, diabetes, and lipid metabolism abnormalities. These protective effects of SIRT1 activation are partly mediated by the deacetylation of p53 and reduction of apoptosis. In this review, we summarize the role of SIRT1 in mediating the pharmacological effects of curcumin in several diseases.

Original languageEnglish
JournalJournal of Cellular Biochemistry
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Sirtuins
Sirtuin 1
Curcumin
Chemical activation
Physiological Phenomena
AMP-Activated Protein Kinases
Phytochemicals
Therapeutic Uses
Adenine
Cell death
Medical problems
Nervous System Diseases
Reperfusion Injury
Nicotine
Lipid Metabolism
Amyloid
Neurons
Glutamic Acid
Fibrosis
Cell Death

Keywords

  • cancer
  • curcumin
  • sirtuin
  • sirtuin-1 (SIRT1)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Impact of curcumin on sirtuins : A review. / Zendedel, Elham; Butler, Alexandra E.; Atkin, Stephen; Sahebkar, Amirhossein.

In: Journal of Cellular Biochemistry, 01.01.2018.

Research output: Contribution to journalArticle

Zendedel, Elham ; Butler, Alexandra E. ; Atkin, Stephen ; Sahebkar, Amirhossein. / Impact of curcumin on sirtuins : A review. In: Journal of Cellular Biochemistry. 2018.
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