Impact of consanguinity on cancer in a highly endogamous population

Abdulbari Bener, Hanadi R. El Ayoubi, Lotfi Chouchane, Awab I. Ali, Aisha Al-Kubaisi, Haya Al-Sulaiti, Ahmad S. Teebi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Many epidemiological studies have indicated that inbreeding has little or no effect on the incidence of cancer. Due to the high prevalence of consanguinity in Qatar(54%), its influence may nevertheless be of special importance. Aim: The aim of this study was to examine whether parental consanguinity affects the risk of cancer in a local Arab highly inbred population. Design: Matched case-control study. Setting: The study was carried out in Al-Amal cancer hospital and primary health care centers in Qatar over a period from August 2008 to February 2009. Subjects and Methods: The study included 370 Qataris and other Arab expatriates with various types of cancers and 635 controls matched by age and ethnicity. A questionnaire that included sociodemographic information, type of consanguinity, medical history, and tumor grade was designed to collect the information of cases and controls. Results: The study revealed that the rate of parental consanguinity was similar in both cases (29.5%) and controls (29.9%) with a higher inbreeding coefficient in controls (0.017±0.03), compared to cancer patients (0.0155±0.03). Other Arab expatriates had a higher incidence of cancer (61.1%) than Qataris (38.9%). The inbreeding coefficient was higher in male cancer patients (0.0189±0.03), but lower in female cancer patients (0.014±0.03) as compared to controls. Controls were more inbred in the overall studied subjects (23.6%) and women (23.8%) than cases. The coefficient of inbreeding was lower in patients with breast (0.014), skin (0.012), thyroid (0.008) and female genital (0.014) cancers, whereas it was higher in cases for leukemia and lymphoma (0.018), colorectal (0.025) and prostate (0.017), with no significant difference between cases and controls. No significant differences were observed between cases and controls in the parental consanguinity, mean coefficient of inbreeding and proportion of more inbred subjects. Conclusions: The study findings revealed that although the consanguinity rate is high in our Arab population, it has no effect on the incidence of cancers overall. However, there was an increased risk found for leukemia and lymphoma, colorectal and prostate cancer groups, but a reduced risk in breast, skin, thyroid and female genital cancer groups.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue number1
Publication statusPublished - 2009

Fingerprint

Consanguinity
Inbreeding
Population
Neoplasms
Qatar
Lymphoma
Incidence
Thyroid Gland
Leukemia
Breast
Cancer Care Facilities
Skin
Case-Control Studies
Epidemiologic Studies
Prostate
Colorectal Neoplasms
Prostatic Neoplasms
Primary Health Care

Keywords

  • Cancer incidence
  • Consanguinityl
  • Qatar

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Bener, A., El Ayoubi, H. R., Chouchane, L., Ali, A. I., Al-Kubaisi, A., Al-Sulaiti, H., & Teebi, A. S. (2009). Impact of consanguinity on cancer in a highly endogamous population. Asian Pacific Journal of Cancer Prevention, 10(1), 35-40.

Impact of consanguinity on cancer in a highly endogamous population. / Bener, Abdulbari; El Ayoubi, Hanadi R.; Chouchane, Lotfi; Ali, Awab I.; Al-Kubaisi, Aisha; Al-Sulaiti, Haya; Teebi, Ahmad S.

In: Asian Pacific Journal of Cancer Prevention, Vol. 10, No. 1, 2009, p. 35-40.

Research output: Contribution to journalArticle

Bener, A, El Ayoubi, HR, Chouchane, L, Ali, AI, Al-Kubaisi, A, Al-Sulaiti, H & Teebi, AS 2009, 'Impact of consanguinity on cancer in a highly endogamous population', Asian Pacific Journal of Cancer Prevention, vol. 10, no. 1, pp. 35-40.
Bener A, El Ayoubi HR, Chouchane L, Ali AI, Al-Kubaisi A, Al-Sulaiti H et al. Impact of consanguinity on cancer in a highly endogamous population. Asian Pacific Journal of Cancer Prevention. 2009;10(1):35-40.
Bener, Abdulbari ; El Ayoubi, Hanadi R. ; Chouchane, Lotfi ; Ali, Awab I. ; Al-Kubaisi, Aisha ; Al-Sulaiti, Haya ; Teebi, Ahmad S. / Impact of consanguinity on cancer in a highly endogamous population. In: Asian Pacific Journal of Cancer Prevention. 2009 ; Vol. 10, No. 1. pp. 35-40.
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abstract = "Background: Many epidemiological studies have indicated that inbreeding has little or no effect on the incidence of cancer. Due to the high prevalence of consanguinity in Qatar(54{\%}), its influence may nevertheless be of special importance. Aim: The aim of this study was to examine whether parental consanguinity affects the risk of cancer in a local Arab highly inbred population. Design: Matched case-control study. Setting: The study was carried out in Al-Amal cancer hospital and primary health care centers in Qatar over a period from August 2008 to February 2009. Subjects and Methods: The study included 370 Qataris and other Arab expatriates with various types of cancers and 635 controls matched by age and ethnicity. A questionnaire that included sociodemographic information, type of consanguinity, medical history, and tumor grade was designed to collect the information of cases and controls. Results: The study revealed that the rate of parental consanguinity was similar in both cases (29.5{\%}) and controls (29.9{\%}) with a higher inbreeding coefficient in controls (0.017±0.03), compared to cancer patients (0.0155±0.03). Other Arab expatriates had a higher incidence of cancer (61.1{\%}) than Qataris (38.9{\%}). The inbreeding coefficient was higher in male cancer patients (0.0189±0.03), but lower in female cancer patients (0.014±0.03) as compared to controls. Controls were more inbred in the overall studied subjects (23.6{\%}) and women (23.8{\%}) than cases. The coefficient of inbreeding was lower in patients with breast (0.014), skin (0.012), thyroid (0.008) and female genital (0.014) cancers, whereas it was higher in cases for leukemia and lymphoma (0.018), colorectal (0.025) and prostate (0.017), with no significant difference between cases and controls. No significant differences were observed between cases and controls in the parental consanguinity, mean coefficient of inbreeding and proportion of more inbred subjects. Conclusions: The study findings revealed that although the consanguinity rate is high in our Arab population, it has no effect on the incidence of cancers overall. However, there was an increased risk found for leukemia and lymphoma, colorectal and prostate cancer groups, but a reduced risk in breast, skin, thyroid and female genital cancer groups.",
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AU - Al-Kubaisi, Aisha

AU - Al-Sulaiti, Haya

AU - Teebi, Ahmad S.

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N2 - Background: Many epidemiological studies have indicated that inbreeding has little or no effect on the incidence of cancer. Due to the high prevalence of consanguinity in Qatar(54%), its influence may nevertheless be of special importance. Aim: The aim of this study was to examine whether parental consanguinity affects the risk of cancer in a local Arab highly inbred population. Design: Matched case-control study. Setting: The study was carried out in Al-Amal cancer hospital and primary health care centers in Qatar over a period from August 2008 to February 2009. Subjects and Methods: The study included 370 Qataris and other Arab expatriates with various types of cancers and 635 controls matched by age and ethnicity. A questionnaire that included sociodemographic information, type of consanguinity, medical history, and tumor grade was designed to collect the information of cases and controls. Results: The study revealed that the rate of parental consanguinity was similar in both cases (29.5%) and controls (29.9%) with a higher inbreeding coefficient in controls (0.017±0.03), compared to cancer patients (0.0155±0.03). Other Arab expatriates had a higher incidence of cancer (61.1%) than Qataris (38.9%). The inbreeding coefficient was higher in male cancer patients (0.0189±0.03), but lower in female cancer patients (0.014±0.03) as compared to controls. Controls were more inbred in the overall studied subjects (23.6%) and women (23.8%) than cases. The coefficient of inbreeding was lower in patients with breast (0.014), skin (0.012), thyroid (0.008) and female genital (0.014) cancers, whereas it was higher in cases for leukemia and lymphoma (0.018), colorectal (0.025) and prostate (0.017), with no significant difference between cases and controls. No significant differences were observed between cases and controls in the parental consanguinity, mean coefficient of inbreeding and proportion of more inbred subjects. Conclusions: The study findings revealed that although the consanguinity rate is high in our Arab population, it has no effect on the incidence of cancers overall. However, there was an increased risk found for leukemia and lymphoma, colorectal and prostate cancer groups, but a reduced risk in breast, skin, thyroid and female genital cancer groups.

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