Immunosuppressive drug therapy

Choli Hartono, Thangamani Muthukumar, Manikkam Suthanthiran

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The first successful kidney transplantation between monozygotic identical twins did not require any immunosuppressive drugs. Clinical application of azathioprine and glucocorticosteroids allowed the transfer of organs between genetically disparate donors and recipients. Transplantation is now the standard of care, a life-saving procedure for patients with failed organs. Progress in our understanding of the immunobiology of rejection has been translated to the development of immunosuppressive agents targeting T cells, B cells, plasma cells, costimulatory signals, complement products, and antidonor antibodies. Modern immunopharmacologic interventions have contributed to the clinical success observed following transplantation but challenges remain in personalizing immunosuppressive therapy.

Original languageEnglish
JournalCold Spring Harbor perspectives in medicine
Volume3
Issue number9
DOIs
Publication statusPublished - 17 Sep 2013
Externally publishedYes

Fingerprint

Drug therapy
Immunosuppressive Agents
Monozygotic Twins
Drug Therapy
Transplantation
T-cells
Azathioprine
Standard of Care
Plasma Cells
Kidney Transplantation
B-Lymphocytes
Cells
Tissue Donors
T-Lymphocytes
Plasmas
Antibodies
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Immunosuppressive drug therapy. / Hartono, Choli; Muthukumar, Thangamani; Suthanthiran, Manikkam.

In: Cold Spring Harbor perspectives in medicine, Vol. 3, No. 9, 17.09.2013.

Research output: Contribution to journalArticle

Hartono, Choli ; Muthukumar, Thangamani ; Suthanthiran, Manikkam. / Immunosuppressive drug therapy. In: Cold Spring Harbor perspectives in medicine. 2013 ; Vol. 3, No. 9.
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