Immunosuppressive drug therapy

Choli Hartono, Thangamani Muthukumar, Manikkam Suthanthiran

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The first successful kidney transplantation between monozygotic identical twins did not require any immunosuppressive drugs. Clinical application of azathioprine and glucocorticosteroids allowed the transfer of organs between genetically disparate donors and recipients. Transplantation is now the standard of care, a life-saving procedure for patients with failed organs. Progress in our understanding of the immunobiology of rejection has been translated to the development of immunosuppressive agents targeting T cells, B cells, plasma cells, costimulatory signals, complement products, and antidonor antibodies. Modern immunopharmacologic interventions have contributed to the clinical success observed following transplantation but challenges remain in personalizing immunosuppressive therapy.

Original languageEnglish
JournalCold Spring Harbor perspectives in medicine
Volume3
Issue number9
DOIs
Publication statusPublished - 17 Sep 2013
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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