Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders

Martin Caprnda, Peter Kubatka, Katarina Gazdikova, Iveta Gasparova, Vanda Valentova, Nadezda Stollarova, Giampiero La Rocca, Nazarii Kobyliak, Jozef Dragasek, Ioana Mozos, Robert Prosecky, Dario Siniscalco, Dietrich Busselberg, Luis Rodrigo, Peter Kruzliak

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Stem cells have the capability of self-renewal and can differentiate into different cell types that might be used in regenerative medicine. Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) currently lack effective treatments. Although stem cell therapy is still on the way from bench to bedside, we consider that it might provide new hope for patients suffering with neurodegenerative diseases. In this article, we will give an overview of recent studies on the potential therapeutic use of mesenchymal stem cells (MSCs), neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and perinatal stem cells to neurodegenerative disorders and we will describe their immunomodulatory mechanisms of action in specific therapeutic modalities.

Original languageEnglish
Pages (from-to)60-69
Number of pages10
JournalBiomedicine and Pharmacotherapy
Volume91
DOIs
Publication statusPublished - 1 Jul 2017

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Keywords

  • Neurodegenerative disorders
  • Regenerative medicine
  • Stem cell therapy

ASJC Scopus subject areas

  • Pharmacology

Cite this

Caprnda, M., Kubatka, P., Gazdikova, K., Gasparova, I., Valentova, V., Stollarova, N., La Rocca, G., Kobyliak, N., Dragasek, J., Mozos, I., Prosecky, R., Siniscalco, D., Busselberg, D., Rodrigo, L., & Kruzliak, P. (2017). Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders. Biomedicine and Pharmacotherapy, 91, 60-69. https://doi.org/10.1016/j.biopha.2017.04.034