Immunobiology and immunopharmacology of organ allograft rejection

Manikkam Suthanthiran, Terry B. Strom

Research output: Contribution to journalArticle

37 Citations (Scopus)


Much has been learned regarding immunobiological mechanisms responsible for the rejection of histoincompatible allografts. There has also been considerable progress in our understanding of mechanisms responsible for tolerance. The new knowledge gained regarding graft destructive alloimmunity process and the mechanisms of action of immunosuppressants have resulted in solid organ graft survival rates that are in excess of 80% at one year posttransplantation. The principles of tolerance mechanisms are yet to be successfully applied in the clinic. In this review, molecular and cellular mechanisms of action of clinically useful immunosuppressive drugs are reviewed from the perspective of regulation of the anti-allograft repertory.

Original languageEnglish
Pages (from-to)161-171
Number of pages11
JournalJournal of Clinical Immunology
Issue number4
Publication statusPublished - 1 Jul 1995
Externally publishedYes



  • immunobiology
  • immunosuppressive drugs
  • rejection
  • tolerance
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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