Immortalization of epithelial cells in oral carcinogenesis as revealed by genome-wide array comparative genomic hybridization

A meta-analysis

Vui King Vincent-Chong, Iman Salahshourifar, Rozaimi Mohamad Razali, Arif Anwar, Rosnah Binti Zain

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background This purpose of this meta-analysis study was to identify the most frequent and potentially significant copy number alteration (CNA) in oral carcinogenesis. Methods Seven oral squamous cell carcinoma (OSCC)-related publications, corresponding to 312 samples, were identified for this meta-analysis. The data were analyzed in a 4-step process that included the genome assembly coordination of multiple platforms, assignment of chromosomal position anchors, calling gains and losses, and functional annotation analysis. Results Gains were more frequent than losses in the entire dataset. High-frequency gains were identified in chromosomes 5p, 14q, 11q, 7p, 17q, 20q, 8q, and 3q, whereas high-frequency losses were identified in chromosomes 3p, 8p, 6p, 18q, and 4q. Ingenuity pathway analysis showed that the top biological function was associated with immortalization of the epithelial cells (p = 1.93E-04). Conclusion This study has identified multiple recurrent CNAs that are involved in various biological annotations associated with oral carcinogenesis.

Original languageEnglish
Pages (from-to)E783-E797
JournalHead and Neck
Volume38
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

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Comparative Genomic Hybridization
Meta-Analysis
Carcinogenesis
Chromosomes
Epithelial Cells
Genome
Squamous Cell Carcinoma
Datasets

Keywords

  • array comparative genomic hybridization (CGH)
  • copy number alteration
  • meta-analysis
  • oral carcinogenesis
  • oral squamous cell carcinoma (OSCC)

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Immortalization of epithelial cells in oral carcinogenesis as revealed by genome-wide array comparative genomic hybridization : A meta-analysis. / Vincent-Chong, Vui King; Salahshourifar, Iman; Mohamad Razali, Rozaimi; Anwar, Arif; Zain, Rosnah Binti.

In: Head and Neck, Vol. 38, 01.04.2016, p. E783-E797.

Research output: Contribution to journalArticle

Vincent-Chong, Vui King ; Salahshourifar, Iman ; Mohamad Razali, Rozaimi ; Anwar, Arif ; Zain, Rosnah Binti. / Immortalization of epithelial cells in oral carcinogenesis as revealed by genome-wide array comparative genomic hybridization : A meta-analysis. In: Head and Neck. 2016 ; Vol. 38. pp. E783-E797.
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