Ikaros transcription factors: Flying between stress and inflammation

George P. Chrousos, Tomoshige Kino

Research output: Contribution to journalReview article

15 Citations (Scopus)


The hypothalamic-pituitary-adrenal axis (a major component of the stress system) and the immune system contribute to the maintenance of homeostasis at rest and during stress. Because of their essential roles for the survival of self and species, the activities of these systems have evolutionarily developed in parallel and are intertwined at many levels. In this issue of the JCI, Ezzat et al. demonstrate that Ikaros, a differentiation factor of leukocyte lineage, also influences the maturation of the fetal pituitary corticotroph and, hence, the secretion of adrenocorticotropic hormone before and after birth (see the related article beginning on page 1021). These results indicate that Ikaros is an ontogenetic and phylogenetic integrator of the stress and immune systems and that abnormalities in its function may produce endocrine and/or immune pathologies.

Original languageEnglish
Pages (from-to)844-848
Number of pages5
JournalJournal of Clinical Investigation
Issue number4
Publication statusPublished - Apr 2005
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

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