IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls

A. S. Bansal, B. Abdul-Karim, Rayaz Malik, P. Goulding, R. S H Pumphrey, A. J M Boulton, P. L J Holt, P. B. Wilson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Aims - To compare the titre of antiganglioside antibodies (AGA) to GM1 ganglioside in patients with central and peripheral neurological disease and pure motor and sensorimotor neuropathy, in patients with classic autoimmune diseases, and controls. Methods - AGA to GM1 were measured using an enzyme linked immunosorbent assay (ELISA) technique, highly purified bovine GM1 ganglioside, and sequential dilution of control and test sera. Antibody titre was calculated using the optical density readings of three consecutive serum dilutions multiplied by the dilution factor. Results - A considerable overlap was evident in the titre of AGA to GM1 in control and test sera. High antibody titres were most frequent in patients with multifocal motor neuropathy with conduction block (MMNCB). Low AGA titre were observed in several patient groups. Compared with the controls, the median titre of AGA to GM1 was significantly higher in patients with multiple sclerosis, rheumatoid arthritis, primary Sjogren's syndrome and systemic lupus erythematosus. In contrast, the median titre in patients with diabetic peripheral neuropathy, motor neurone disease, sensorimotor neuropathy and chronic inflammatory demyelinating polyneuropathy was no different from that in normal control subjects. Conclusions - Estimation of AGA to GM1 may be helpful in the diagnosis of MMNCB in patients with a pure motor neuropathy but in few other conditions. Low titre AGA to GM1 are evident in several autoimmune conditions. The pathogenetic importance of AGA to GM1 in patients with neuropathy is not clear.

Original languageEnglish
Pages (from-to)300-302
Number of pages3
JournalJournal of Clinical Pathology
Volume47
Issue number4
Publication statusPublished - 1994
Externally publishedYes

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G(M1) Ganglioside
Autoimmune Diseases
Immunoglobulin M
Antibodies
Serum
Immunosorbent Techniques
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Motor Neuron Disease
Diabetic Neuropathies
Sjogren's Syndrome
Peripheral Nervous System Diseases
Systemic Lupus Erythematosus
Multiple Sclerosis
Reading
Rheumatoid Arthritis
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Bansal, A. S., Abdul-Karim, B., Malik, R., Goulding, P., Pumphrey, R. S. H., Boulton, A. J. M., ... Wilson, P. B. (1994). IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls. Journal of Clinical Pathology, 47(4), 300-302.

IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls. / Bansal, A. S.; Abdul-Karim, B.; Malik, Rayaz; Goulding, P.; Pumphrey, R. S H; Boulton, A. J M; Holt, P. L J; Wilson, P. B.

In: Journal of Clinical Pathology, Vol. 47, No. 4, 1994, p. 300-302.

Research output: Contribution to journalArticle

Bansal, AS, Abdul-Karim, B, Malik, R, Goulding, P, Pumphrey, RSH, Boulton, AJM, Holt, PLJ & Wilson, PB 1994, 'IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls', Journal of Clinical Pathology, vol. 47, no. 4, pp. 300-302.
Bansal AS, Abdul-Karim B, Malik R, Goulding P, Pumphrey RSH, Boulton AJM et al. IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls. Journal of Clinical Pathology. 1994;47(4):300-302.
Bansal, A. S. ; Abdul-Karim, B. ; Malik, Rayaz ; Goulding, P. ; Pumphrey, R. S H ; Boulton, A. J M ; Holt, P. L J ; Wilson, P. B. / IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls. In: Journal of Clinical Pathology. 1994 ; Vol. 47, No. 4. pp. 300-302.
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T1 - IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls

AU - Bansal, A. S.

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AU - Malik, Rayaz

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AU - Pumphrey, R. S H

AU - Boulton, A. J M

AU - Holt, P. L J

AU - Wilson, P. B.

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