Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3

Assumpció Bosch, Jordi Guimerà, Stefan Wiemann, Wilhelm Ansorge, David Patterson, Xavier P. Estivill

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two highly polymorphic CA-repeat microsatellites (D21S1224 and D21S1261) are reported. The clones containing these CA-repeats (ABM-C60 and ABM-C29) have been isolated from a human chromosome-21-specific library (LA21NS01) and have been localised to the q22.3 band using a specific chromosome 21 somatic cell hybrid panel. Both polymorphisms showed heterozygosities of 0.83 in the unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These new markers should improve the map of the 21q22.3 region, which is believed to contain a large number of genes.

Original languageEnglish
Pages (from-to)367-369
Number of pages3
JournalHuman Genetics
Volume95
Issue number3
DOIs
Publication statusPublished - Mar 1995
Externally publishedYes

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Chromosomes, Human, Pair 21
Human Chromosomes
Hybrid Cells
Microsatellite Repeats
Libraries
Clone Cells
Genes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3. / Bosch, Assumpció; Guimerà, Jordi; Wiemann, Stefan; Ansorge, Wilhelm; Patterson, David; Estivill, Xavier P.

In: Human Genetics, Vol. 95, No. 3, 03.1995, p. 367-369.

Research output: Contribution to journalArticle

Bosch, Assumpció ; Guimerà, Jordi ; Wiemann, Stefan ; Ansorge, Wilhelm ; Patterson, David ; Estivill, Xavier P. / Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3. In: Human Genetics. 1995 ; Vol. 95, No. 3. pp. 367-369.
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