Identification of deletion mutations and three new genes at the familial polyposis locus

Geoff Joslyn, Mary Carlson, Andrew Thliveris, Hans Albertsen, Lawrence Gelbert, Wade Samowitz, Joanna Groden, Jeff Stevens, Lisa Spirio, Margaret Robertson, Leslie Sargeant, Karen Krapcho, Erika Wolff, Randall Burt, J. P. Hughes, Janet Warrington, John McPherson, John Wasmuth, Denis Le Paslier, Hadi AbderrahimDaniel Cohen, Mark Leppert, Ray White

Research output: Contribution to journalArticle

636 Citations (Scopus)

Abstract

Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.

Original languageEnglish
Pages (from-to)601-619
Number of pages19
JournalCell
Volume66
Issue number3
Publication statusPublished - 1 Dec 1991
Externally publishedYes

Fingerprint

Sequence Deletion
Genes
MCC Genes
Signal Recognition Particle
Adenomatous Polyposis Coli
Complementary DNA
DNA

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Joslyn, G., Carlson, M., Thliveris, A., Albertsen, H., Gelbert, L., Samowitz, W., ... White, R. (1991). Identification of deletion mutations and three new genes at the familial polyposis locus. Cell, 66(3), 601-619.

Identification of deletion mutations and three new genes at the familial polyposis locus. / Joslyn, Geoff; Carlson, Mary; Thliveris, Andrew; Albertsen, Hans; Gelbert, Lawrence; Samowitz, Wade; Groden, Joanna; Stevens, Jeff; Spirio, Lisa; Robertson, Margaret; Sargeant, Leslie; Krapcho, Karen; Wolff, Erika; Burt, Randall; Hughes, J. P.; Warrington, Janet; McPherson, John; Wasmuth, John; Le Paslier, Denis; Abderrahim, Hadi; Cohen, Daniel; Leppert, Mark; White, Ray.

In: Cell, Vol. 66, No. 3, 01.12.1991, p. 601-619.

Research output: Contribution to journalArticle

Joslyn, G, Carlson, M, Thliveris, A, Albertsen, H, Gelbert, L, Samowitz, W, Groden, J, Stevens, J, Spirio, L, Robertson, M, Sargeant, L, Krapcho, K, Wolff, E, Burt, R, Hughes, JP, Warrington, J, McPherson, J, Wasmuth, J, Le Paslier, D, Abderrahim, H, Cohen, D, Leppert, M & White, R 1991, 'Identification of deletion mutations and three new genes at the familial polyposis locus', Cell, vol. 66, no. 3, pp. 601-619.
Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W et al. Identification of deletion mutations and three new genes at the familial polyposis locus. Cell. 1991 Dec 1;66(3):601-619.
Joslyn, Geoff ; Carlson, Mary ; Thliveris, Andrew ; Albertsen, Hans ; Gelbert, Lawrence ; Samowitz, Wade ; Groden, Joanna ; Stevens, Jeff ; Spirio, Lisa ; Robertson, Margaret ; Sargeant, Leslie ; Krapcho, Karen ; Wolff, Erika ; Burt, Randall ; Hughes, J. P. ; Warrington, Janet ; McPherson, John ; Wasmuth, John ; Le Paslier, Denis ; Abderrahim, Hadi ; Cohen, Daniel ; Leppert, Mark ; White, Ray. / Identification of deletion mutations and three new genes at the familial polyposis locus. In: Cell. 1991 ; Vol. 66, No. 3. pp. 601-619.
@article{eb1aab05d1e646269ba9fbda60d0668f,
title = "Identification of deletion mutations and three new genes at the familial polyposis locus",
abstract = "Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.",
author = "Geoff Joslyn and Mary Carlson and Andrew Thliveris and Hans Albertsen and Lawrence Gelbert and Wade Samowitz and Joanna Groden and Jeff Stevens and Lisa Spirio and Margaret Robertson and Leslie Sargeant and Karen Krapcho and Erika Wolff and Randall Burt and Hughes, {J. P.} and Janet Warrington and John McPherson and John Wasmuth and {Le Paslier}, Denis and Hadi Abderrahim and Daniel Cohen and Mark Leppert and Ray White",
year = "1991",
month = "12",
day = "1",
language = "English",
volume = "66",
pages = "601--619",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Identification of deletion mutations and three new genes at the familial polyposis locus

AU - Joslyn, Geoff

AU - Carlson, Mary

AU - Thliveris, Andrew

AU - Albertsen, Hans

AU - Gelbert, Lawrence

AU - Samowitz, Wade

AU - Groden, Joanna

AU - Stevens, Jeff

AU - Spirio, Lisa

AU - Robertson, Margaret

AU - Sargeant, Leslie

AU - Krapcho, Karen

AU - Wolff, Erika

AU - Burt, Randall

AU - Hughes, J. P.

AU - Warrington, Janet

AU - McPherson, John

AU - Wasmuth, John

AU - Le Paslier, Denis

AU - Abderrahim, Hadi

AU - Cohen, Daniel

AU - Leppert, Mark

AU - White, Ray

PY - 1991/12/1

Y1 - 1991/12/1

N2 - Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.

AB - Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.

UR - http://www.scopus.com/inward/record.url?scp=0025941471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025941471&partnerID=8YFLogxK

M3 - Article

C2 - 1678319

AN - SCOPUS:0025941471

VL - 66

SP - 601

EP - 619

JO - Cell

JF - Cell

SN - 0092-8674

IS - 3

ER -