Identification of cancer drug sensitivity biomarkers

Ehsan Ullah, RaghvenPhDa Mall, Halima Bensmail, Reda Rawi, Saila Shama, Nooral Al Muftah, Ian Richard Thmpson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Anti-cancer therapies have different responses to different patients. There is a need to identify biomarkers for effectiveness of drugs beside the biomarkers for the diseases like cancer to advance the field personalized medicine. We have used a panel of cancer cell lines from Genomics of Drug Sensitivity in Cancer (GDSC) to capture the sensitivity of drugs. By combining the genetic information such as mutations, copy number variations and gene expression levels from Catalogue of Somatic Mutations in Cancer (COSMIC) and The Cancer Genome ATLAS (TCGA) for the afore mentioned cell lines, we are able to identify genomic features associated with the sensitivity of the drugs.

Original languageEnglish
Title of host publicationProceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2322-2324
Number of pages3
Volume2017-January
ISBN (Electronic)9781509030491
DOIs
Publication statusPublished - 15 Dec 2017
Event2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017 - Kansas City, United States
Duration: 13 Nov 201716 Nov 2017

Other

Other2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
CountryUnited States
CityKansas City
Period13/11/1716/11/17

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Keywords

  • association analysis
  • biomarkers
  • cancer
  • drug sensitivity
  • genomics
  • statistical analysis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

Cite this

Ullah, E., Mall, R., Bensmail, H., Rawi, R., Shama, S., Muftah, N. A., & Thmpson, I. R. (2017). Identification of cancer drug sensitivity biomarkers. In Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017 (Vol. 2017-January, pp. 2322-2324). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2017.8218043