Hypoxic neuropathy

relevance to human diabetic neuropathy

Rayaz Malik, E. A. Masson, A. K. Sharma, R. H. Lye, A. K. Ah-See, A. M. Compton, D. R. Tomlinson, S. P. Hanley, A. J M Boulton

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Clinical and neurophysiological studies were conducted in 47 patients with chronic obstructive airways disease and compared with 46 age-matched control subjects. Symptomatic neuropathy was reported in 13% and ankle jerks were absent in 45% of hypoxic patients. Peroneal and median nerve conduction velocities and median and sural sensory nerve amplitudes were significantly reduced in hypoxic patients (p<0.01). Six hypoxic patients underwent biopsy of the sural nerve, soleus muscle and overlying skin. Nerve glucose, sorbitol, fructose and myo-inositol concentrations were normal. Detailed light and electronrmicroscopy revealed both nerve fibre and microvascular pathology. Segmental demyelination (32%) and unmyelinated fibre degeneration were found to be prominent lesions. The sural nerve perineurium was thickened due to an increase in the number of perineurial lamellae and an increase in intraperineurial space. Basement membrane thickening was observed in capillaries of nerve, muscle and skin. Endothelial cell hyperplasia and hypertrophy were observed in nerve and muscle capillaries but not in skin capillaries. In conclusion, this study has provided neurological, neurophysiological and neuropathological evidence of a neuropathy in hypoxic patients with chronic obstructive airways disease. These findings may be of relevance to some aspects of the aetiology of human diabetic neuropathy.

Original languageEnglish
Pages (from-to)311-318
Number of pages8
JournalDiabetologia
Volume33
Issue number5
DOIs
Publication statusPublished - May 1990
Externally publishedYes

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Diabetic Neuropathies
Sural Nerve
Chronic Obstructive Pulmonary Disease
Skin
Muscles
Peroneal Nerve
Sorbitol
Median Nerve
Neural Conduction
Demyelinating Diseases
Inositol
Fructose
Peripheral Nerves
Nerve Fibers
Basement Membrane
Ankle
Hypertrophy
Hyperplasia
Skeletal Muscle
Endothelial Cells

Keywords

  • diabetes
  • Hypoxia
  • microangiopathy
  • neuropathy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Malik, R., Masson, E. A., Sharma, A. K., Lye, R. H., Ah-See, A. K., Compton, A. M., ... Boulton, A. J. M. (1990). Hypoxic neuropathy: relevance to human diabetic neuropathy. Diabetologia, 33(5), 311-318. https://doi.org/10.1007/BF00403326

Hypoxic neuropathy : relevance to human diabetic neuropathy. / Malik, Rayaz; Masson, E. A.; Sharma, A. K.; Lye, R. H.; Ah-See, A. K.; Compton, A. M.; Tomlinson, D. R.; Hanley, S. P.; Boulton, A. J M.

In: Diabetologia, Vol. 33, No. 5, 05.1990, p. 311-318.

Research output: Contribution to journalArticle

Malik, R, Masson, EA, Sharma, AK, Lye, RH, Ah-See, AK, Compton, AM, Tomlinson, DR, Hanley, SP & Boulton, AJM 1990, 'Hypoxic neuropathy: relevance to human diabetic neuropathy', Diabetologia, vol. 33, no. 5, pp. 311-318. https://doi.org/10.1007/BF00403326
Malik R, Masson EA, Sharma AK, Lye RH, Ah-See AK, Compton AM et al. Hypoxic neuropathy: relevance to human diabetic neuropathy. Diabetologia. 1990 May;33(5):311-318. https://doi.org/10.1007/BF00403326
Malik, Rayaz ; Masson, E. A. ; Sharma, A. K. ; Lye, R. H. ; Ah-See, A. K. ; Compton, A. M. ; Tomlinson, D. R. ; Hanley, S. P. ; Boulton, A. J M. / Hypoxic neuropathy : relevance to human diabetic neuropathy. In: Diabetologia. 1990 ; Vol. 33, No. 5. pp. 311-318.
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