Hypothalamic-Pituitary-Adrenocortical Activity in Patients With Diabetes Mellitus

Oliver G. Cameron, Ziad Kronfol, John F. Greden, Bernard J. Carroll

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Several clinical and physiologic associations between depression and diabetes mellitus have been reported. In this study, a potential neuroendocrine association was studied by measuring hypothalamic-pituitary-adrenocortical (HPA) axis activity in patients with diabetes mellitus. Plasma cortisol levels and response to dexamethasone administration were determined in 54 diabetics. Twenty-three (55%) of forty-two 1-mg dexamethasone suppression tests (DSTs) performed in 34 subjects, with eight repeated tests, and two (10%) of twenty 2-mg DSTs demonstrated a blunting of normal suppression. None of a variety of potential demographic, physiologic, or mood factors predicted nonsuppression. This study replicates prior findings that HPA dysfunction occurs in association with diabetes, and invalidates the use of the 1-mg DST as a diagnostic marker for melancholia in patients with diabetes.

Original languageEnglish
Pages (from-to)1090-1095
Number of pages6
JournalArchives of General Psychiatry
Volume41
Issue number11
DOIs
Publication statusPublished - 1984
Externally publishedYes

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Dexamethasone
Diabetes Mellitus
Depressive Disorder
Hydrocortisone
Demography
Depression
Suppression
Diabetes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Hypothalamic-Pituitary-Adrenocortical Activity in Patients With Diabetes Mellitus. / Cameron, Oliver G.; Kronfol, Ziad; Greden, John F.; Carroll, Bernard J.

In: Archives of General Psychiatry, Vol. 41, No. 11, 1984, p. 1090-1095.

Research output: Contribution to journalArticle

Cameron, Oliver G. ; Kronfol, Ziad ; Greden, John F. ; Carroll, Bernard J. / Hypothalamic-Pituitary-Adrenocortical Activity in Patients With Diabetes Mellitus. In: Archives of General Psychiatry. 1984 ; Vol. 41, No. 11. pp. 1090-1095.
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