Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR

LA-cp rodent model of dyslipidemia and cardiac dysfunction

Abdoulaye Diane, Faye Borthwick, Sheng Wu, Jeanette Lee, Paula N. Brown, Timothy A. Dickinson, Kevin D. Croft, Donna F. Vine, Spencer D. Proctor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hawthorn is a widely used herbal alternative medicine for the treatment of various cardiovascular diseases. However, the attributed health benefits, purported to be due to the presence of phenolic compounds, may depend on both the specific species and plant part. Studies to date investigating effects of hawthorn on heart disease(s) have used well-described European and/or Asian species, while little is known regarding the bioactivity of species native to North America. Six weeks of supplementation of both fireberry hawthorn berry (native Crataegus chrysocarpa) and English hawthorn leaf (C. monogyna, naturalized in North America) in the JCR:LA-cp rat, resulted in a significant reduction in heart weight, fasting LDL-C and improved heart function (p < 0.05). Fasting triglyceride and myocardial fibrosis were also reduced, but only by the berry extract. We demonstrate that both of the Canadian-sourced hawthorn extracts (introduced leaf and native berry) have cardioprotective benefits, likely via increased availability of nitric oxide.

Original languageEnglish
Pages (from-to)3943-3952
Number of pages10
JournalFood and Function
Volume7
Issue number9
DOIs
Publication statusPublished - 1 Sep 2016
Externally publishedYes

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Crataegus
fruit extracts
hyperlipidemia
Dyslipidemias
Rodentia
Fruit
rodents
small fruits
North America
fasting
Fasting
heart
Crataegus monogyna
alternative medicine
Herbal Medicine
extracts
heart diseases
Insurance Benefits
Complementary Therapies
fibrosis

ASJC Scopus subject areas

  • Food Science

Cite this

Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR : LA-cp rodent model of dyslipidemia and cardiac dysfunction. / Diane, Abdoulaye; Borthwick, Faye; Wu, Sheng; Lee, Jeanette; Brown, Paula N.; Dickinson, Timothy A.; Croft, Kevin D.; Vine, Donna F.; Proctor, Spencer D.

In: Food and Function, Vol. 7, No. 9, 01.09.2016, p. 3943-3952.

Research output: Contribution to journalArticle

Diane, A, Borthwick, F, Wu, S, Lee, J, Brown, PN, Dickinson, TA, Croft, KD, Vine, DF & Proctor, SD 2016, 'Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR: LA-cp rodent model of dyslipidemia and cardiac dysfunction', Food and Function, vol. 7, no. 9, pp. 3943-3952. https://doi.org/10.1039/c6fo01023g
Diane, Abdoulaye ; Borthwick, Faye ; Wu, Sheng ; Lee, Jeanette ; Brown, Paula N. ; Dickinson, Timothy A. ; Croft, Kevin D. ; Vine, Donna F. ; Proctor, Spencer D. / Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR : LA-cp rodent model of dyslipidemia and cardiac dysfunction. In: Food and Function. 2016 ; Vol. 7, No. 9. pp. 3943-3952.
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