Abstract
Hawthorn is a widely used herbal alternative medicine for the treatment of various cardiovascular diseases. However, the attributed health benefits, purported to be due to the presence of phenolic compounds, may depend on both the specific species and plant part. Studies to date investigating effects of hawthorn on heart disease(s) have used well-described European and/or Asian species, while little is known regarding the bioactivity of species native to North America. Six weeks of supplementation of both fireberry hawthorn berry (native Crataegus chrysocarpa) and English hawthorn leaf (C. monogyna, naturalized in North America) in the JCR:LA-cp rat, resulted in a significant reduction in heart weight, fasting LDL-C and improved heart function (p < 0.05). Fasting triglyceride and myocardial fibrosis were also reduced, but only by the berry extract. We demonstrate that both of the Canadian-sourced hawthorn extracts (introduced leaf and native berry) have cardioprotective benefits, likely via increased availability of nitric oxide.
| Original language | English |
|---|---|
| Pages (from-to) | 3943-3952 |
| Number of pages | 10 |
| Journal | Food and Function |
| Volume | 7 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 Sep 2016 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Food Science
Cite this
Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR : LA-cp rodent model of dyslipidemia and cardiac dysfunction. / Diane, Abdoulaye; Borthwick, Faye; Wu, Sheng; Lee, Jeanette; Brown, Paula N.; Dickinson, Timothy A.; Croft, Kevin D.; Vine, Donna F.; Proctor, Spencer D.
In: Food and Function, Vol. 7, No. 9, 01.09.2016, p. 3943-3952.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR
T2 - LA-cp rodent model of dyslipidemia and cardiac dysfunction
AU - Diane, Abdoulaye
AU - Borthwick, Faye
AU - Wu, Sheng
AU - Lee, Jeanette
AU - Brown, Paula N.
AU - Dickinson, Timothy A.
AU - Croft, Kevin D.
AU - Vine, Donna F.
AU - Proctor, Spencer D.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Hawthorn is a widely used herbal alternative medicine for the treatment of various cardiovascular diseases. However, the attributed health benefits, purported to be due to the presence of phenolic compounds, may depend on both the specific species and plant part. Studies to date investigating effects of hawthorn on heart disease(s) have used well-described European and/or Asian species, while little is known regarding the bioactivity of species native to North America. Six weeks of supplementation of both fireberry hawthorn berry (native Crataegus chrysocarpa) and English hawthorn leaf (C. monogyna, naturalized in North America) in the JCR:LA-cp rat, resulted in a significant reduction in heart weight, fasting LDL-C and improved heart function (p < 0.05). Fasting triglyceride and myocardial fibrosis were also reduced, but only by the berry extract. We demonstrate that both of the Canadian-sourced hawthorn extracts (introduced leaf and native berry) have cardioprotective benefits, likely via increased availability of nitric oxide.
AB - Hawthorn is a widely used herbal alternative medicine for the treatment of various cardiovascular diseases. However, the attributed health benefits, purported to be due to the presence of phenolic compounds, may depend on both the specific species and plant part. Studies to date investigating effects of hawthorn on heart disease(s) have used well-described European and/or Asian species, while little is known regarding the bioactivity of species native to North America. Six weeks of supplementation of both fireberry hawthorn berry (native Crataegus chrysocarpa) and English hawthorn leaf (C. monogyna, naturalized in North America) in the JCR:LA-cp rat, resulted in a significant reduction in heart weight, fasting LDL-C and improved heart function (p < 0.05). Fasting triglyceride and myocardial fibrosis were also reduced, but only by the berry extract. We demonstrate that both of the Canadian-sourced hawthorn extracts (introduced leaf and native berry) have cardioprotective benefits, likely via increased availability of nitric oxide.
UR - http://www.scopus.com/inward/record.url?scp=84987875339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84987875339&partnerID=8YFLogxK
U2 - 10.1039/c6fo01023g
DO - 10.1039/c6fo01023g
M3 - Article
C2 - 27538786
AN - SCOPUS:84987875339
VL - 7
SP - 3943
EP - 3952
JO - Food and Function
JF - Food and Function
SN - 2042-6496
IS - 9
ER -