Hypertension in pregnancy is a risk factor for microalbuminuria later in life

Andrea G. Kattah, Reem Asad, Dawn C. Scantlebury, Kent R. Bailey, Heather J. Wiste, Steven C. Hunt, Thomas H. Mosley, Sharon L R Kardia, Stephen T. Turner, Vesna D. Garovic

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The authors aimed to compare renal function by estimated glomerular filtration rate and albuminuria in 3 groups of women: nulliparous women, women with a history of normotensive pregnancies, and women with a history of at least one hypertensive pregnancy. Women who participated in the second Family Blood Pressure Program Study visit (2000-2004) and had serum creatinine and urine albumin measurements (n=3015) were categorized as having had no pregnancy lasting >6 months (n=341), having had only normotensive pregnancies (n=2199), or having had at least 1 pregnancy with hypertension (n=475) based on a standardized questionnaire. Women who reported having had at least one pregnancy with hypertension were significantly more likely to be hypertensive (75.6% vs 59.4%, P < .001), diabetic (34.2% vs 27.3%, P ≤ .001), and have higher body mass index (32.8 vs 30.5, P < .001) than those who reported normotensive pregnancies. There was a significantly greater risk of microalbuminuria (urine albumin-creatinine ratio >25 mg/g) in those who reported at least one pregnancy with hypertension (odds ratio, 1.37; confidence interval, 1.02-1.85; P=04) than in those with normotensive pregnancies, after adjusting for risk factors for chronic kidney and cardiovascular disease. Hypertension in pregnancy is associated with an increased risk of future microalbuminuria.

Original languageEnglish
Pages (from-to)617-623
Number of pages7
JournalJournal of Clinical Hypertension
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 2013
Externally publishedYes

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Hypertension
Pregnancy
Reproductive History
Albuminuria
Glomerular Filtration Rate
Chronic Renal Insufficiency
Albumins
Creatinine
Cardiovascular Diseases
Odds Ratio
Urine
Confidence Intervals
Blood Pressure
Kidney
Serum

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Kattah, A. G., Asad, R., Scantlebury, D. C., Bailey, K. R., Wiste, H. J., Hunt, S. C., ... Garovic, V. D. (2013). Hypertension in pregnancy is a risk factor for microalbuminuria later in life. Journal of Clinical Hypertension, 15(9), 617-623. https://doi.org/10.1111/jch.12116

Hypertension in pregnancy is a risk factor for microalbuminuria later in life. / Kattah, Andrea G.; Asad, Reem; Scantlebury, Dawn C.; Bailey, Kent R.; Wiste, Heather J.; Hunt, Steven C.; Mosley, Thomas H.; Kardia, Sharon L R; Turner, Stephen T.; Garovic, Vesna D.

In: Journal of Clinical Hypertension, Vol. 15, No. 9, 09.2013, p. 617-623.

Research output: Contribution to journalArticle

Kattah, AG, Asad, R, Scantlebury, DC, Bailey, KR, Wiste, HJ, Hunt, SC, Mosley, TH, Kardia, SLR, Turner, ST & Garovic, VD 2013, 'Hypertension in pregnancy is a risk factor for microalbuminuria later in life', Journal of Clinical Hypertension, vol. 15, no. 9, pp. 617-623. https://doi.org/10.1111/jch.12116
Kattah, Andrea G. ; Asad, Reem ; Scantlebury, Dawn C. ; Bailey, Kent R. ; Wiste, Heather J. ; Hunt, Steven C. ; Mosley, Thomas H. ; Kardia, Sharon L R ; Turner, Stephen T. ; Garovic, Vesna D. / Hypertension in pregnancy is a risk factor for microalbuminuria later in life. In: Journal of Clinical Hypertension. 2013 ; Vol. 15, No. 9. pp. 617-623.
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