Hypertension, dyslipidemia, and insulin resistance: Links in a chain or spokes on a wheel?

Paul N. Hopkins, Steven C. Hunt, Lily L. Wu, Gordon H. Williams, Roger R. Williams

Research output: Contribution to journalReview article

78 Citations (Scopus)


Rather than a link in a causal chain leading to hypertension, insulin resistance and resultant hyperinsulinemia may be 'spokes on a wheel', with central or visceral obesity as the postulated hub of the wheel. Hypertension, hypertriglyceridemia and high density lipoprotein cholesterol are depicted as other spokes. Newly identified metabolic pathways in adipose tissue or the modulating effects of various predisposing genes may lead to variable expression of various components of the multiple metabolic syndrome in individuals with a predisposition to the collection of visceral fat.

Original languageEnglish
Pages (from-to)241-253
Number of pages13
JournalCurrent Opinion in Lipidology
Issue number4
Publication statusPublished - 1 Jan 1996


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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