Hyperprolactinaemia in male infertility: Clinical case scenarios

Zeinab Dabbous, Stephen Atkin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To explore the evaluation, treatment and impact of hyperprolactinaemia on male infertility and testicular function, as hyperprolactinaemia is commonly detected during the evaluation of infertile men. Methods: A literature search was performed using MEDLINE/PubMed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify all studies exploring hyperprolactinaemia in male infertility. Results: Elevated levels of serum prolactin have a detrimental effect on male reproduction through inhibition of the pulsatile release of gonadotrophins from the anterior pituitary gland, and a direct effect on spermatogenesis. Treatment of confirmed hyperprolactinaemia with dopamine agonists leads to significant improvements in both semen parameters and hormone levels. Conclusion: Hyperprolactinaemia, both directly and indirectly, has a negative effect on sperm production, and its detection and management in men seeking fertility is mandatory.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
JournalArab Journal of Urology
Volume16
Issue number1
DOIs
Publication statusPublished - 1 Mar 2018

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Keywords

  • Dopamine agonists
  • Male infertility
  • Pituitary adenoma
  • Prolactin
  • Testosterone

ASJC Scopus subject areas

  • Urology

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