Hyperadiponectinemia is independent of kidney function, diabetes duration, and control in type 1 diabetic patients without microangiopathy

Charbel Abi Khalil, Kamel Mohammedi, Roberte Aubert, Elizabeth Abou Jaoude, Florence Travert, Samy Hadjadj, Frédéric Fumeron, Ronan Roussel, Michel Marre

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction: High total adiponectin (ADPN) levels were reported in type 1 diabetes (T1D) and related to long diabetes duration and nephropathy. We studied whether ADPN and its specific isoforms were elevated in T1D without microangiopathy and whether they were related to kidney function. Materials and Methods: Total, high, medium, and low molecular weight ADPN and insulin levels were measured in 47 consecutive normoalbuminuric, normotensive T1D patients without retinopathy and in 47 age-, sex-, and body mass index-matched controls. Glomerular filtration rate was estimated by 51Cr-EDTA plasma clearance. Results: Total and high molecular weight ADPN ratio were higher in T1D patients than in controls. ADPN levels were not related to anthropometric measures, whereas they were in controls. In T1D, ADPN levels were not related to glycosylated hemoglobin, diabetes duration, or glomerular filtration rate. Peripheral insulin levels were higher in T1D patients than in controls, but they were not related to ADPN levels. In controls, insulin levels were positively related to total ADPN. Conclusion: In T1D without microangiopathy, high ADPN levels could not be related to anthropometric diabetes parameters, kidney function, or high insulin levels. The nature of this elevation remains unknown.

Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number3
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

Fingerprint

Adiponectin
Medical problems
Type 1 Diabetes Mellitus
Kidney
Insulin
Glomerular Filtration Rate
Molecular Weight
Molecular weight
Glycosylated Hemoglobin A
Edetic Acid
Protein Isoforms
Body Mass Index
Plasmas

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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Hyperadiponectinemia is independent of kidney function, diabetes duration, and control in type 1 diabetic patients without microangiopathy. / Abi Khalil, Charbel; Mohammedi, Kamel; Aubert, Roberte; Jaoude, Elizabeth Abou; Travert, Florence; Hadjadj, Samy; Fumeron, Frédéric; Roussel, Ronan; Marre, Michel.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 3, 03.2011.

Research output: Contribution to journalArticle

Abi Khalil, Charbel ; Mohammedi, Kamel ; Aubert, Roberte ; Jaoude, Elizabeth Abou ; Travert, Florence ; Hadjadj, Samy ; Fumeron, Frédéric ; Roussel, Ronan ; Marre, Michel. / Hyperadiponectinemia is independent of kidney function, diabetes duration, and control in type 1 diabetic patients without microangiopathy. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 3.
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T1 - Hyperadiponectinemia is independent of kidney function, diabetes duration, and control in type 1 diabetic patients without microangiopathy

AU - Abi Khalil, Charbel

AU - Mohammedi, Kamel

AU - Aubert, Roberte

AU - Jaoude, Elizabeth Abou

AU - Travert, Florence

AU - Hadjadj, Samy

AU - Fumeron, Frédéric

AU - Roussel, Ronan

AU - Marre, Michel

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N2 - Introduction: High total adiponectin (ADPN) levels were reported in type 1 diabetes (T1D) and related to long diabetes duration and nephropathy. We studied whether ADPN and its specific isoforms were elevated in T1D without microangiopathy and whether they were related to kidney function. Materials and Methods: Total, high, medium, and low molecular weight ADPN and insulin levels were measured in 47 consecutive normoalbuminuric, normotensive T1D patients without retinopathy and in 47 age-, sex-, and body mass index-matched controls. Glomerular filtration rate was estimated by 51Cr-EDTA plasma clearance. Results: Total and high molecular weight ADPN ratio were higher in T1D patients than in controls. ADPN levels were not related to anthropometric measures, whereas they were in controls. In T1D, ADPN levels were not related to glycosylated hemoglobin, diabetes duration, or glomerular filtration rate. Peripheral insulin levels were higher in T1D patients than in controls, but they were not related to ADPN levels. In controls, insulin levels were positively related to total ADPN. Conclusion: In T1D without microangiopathy, high ADPN levels could not be related to anthropometric diabetes parameters, kidney function, or high insulin levels. The nature of this elevation remains unknown.

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