Hyalomma dromedarii (Acari: Ixodidae) Salivary Gland Extract Inhibits Angiogenesis and Exhibits In Vitro Antitumor Effects

Chaima Bensaoud, Zaineb Abdelkafi-Koubaa, Hazem Ben Mabrouk, Maram Morjen, Issam Hmila, Adel Rhim, Mohamed El Ayeb, Naziha Marrakchi, Ali Bouattour, Youmna M'ghirbi

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3 Citations (Scopus)

Abstract

Hard ticks (Acari: Ixodidae) are blood-sucking ectoparasites characterized by the extended period of their attachment to their host. To access their bloodmeal, ticks secrete saliva containing a range of molecules that target the host's inflammation, immune system, and hemostatic components. Some of these molecules reportedly possess antiangiogenic and antitumor properties. The present study describes our investigation, the first of its kind, of the antiangiogenic and antitumoral effects of the Hyalomma dromedarii Koch, 1844 (Acari: Ixodidae), salivary gland extract (SGE), which inhibited the adhesion and migration of Human Umbilical Vein Endothelial Cells (HUVECs) in a dose-dependent manner, as well as angiogenesis in the Chick Chorioallantoic Membrane model. Interestingly, H. dromedarii SGE exerted an antiproliferative effect on U87 glioblastoma cells and inhibited their adhesion and migration to fibrinogen. These results open up new possibilities for characterizing and developing new molecules involved in the key steps of tumor progression.

Original languageEnglish
Pages (from-to)1476-1482
Number of pages7
JournalJournal of Medical Entomology
Volume54
Issue number6
DOIs
Publication statusPublished - 7 Nov 2017
Externally publishedYes

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Keywords

  • antiangiogenic activity
  • antitumor activity
  • hard tick
  • Hyalomma dromedarii
  • salivary gland extract

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

Cite this

Bensaoud, C., Abdelkafi-Koubaa, Z., Ben Mabrouk, H., Morjen, M., Hmila, I., Rhim, A., Ayeb, M. E., Marrakchi, N., Bouattour, A., & M'ghirbi, Y. (2017). Hyalomma dromedarii (Acari: Ixodidae) Salivary Gland Extract Inhibits Angiogenesis and Exhibits In Vitro Antitumor Effects. Journal of Medical Entomology, 54(6), 1476-1482. https://doi.org/10.1093/jme/tjx153