HuR and myogenesis: Being in the right place at the right time

Christopher Von Roretz, Pascal Beauchamp, Sergio Di Marco, Imed Eddine Gallouzi

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

The process of muscle cell differentiation into myotubes, termed myogenesis, depends on a complex coordination of myogenic factors, many of which are regulated post-transcriptionally. HuR, an mRNA-binding protein, is responsible for regulating the expression of several such myogenic factors by stabilizing their mRNAs. The critical role for HuR in myogenesis also involves the nucleocytoplasmic shuttling ability of this protein. Indeed, in order to perform its stabilizing functions, HuR must accumulate in the cytoplasm. This requires its dissociation from the import factor Transportin 2 (TRN2) which is actually caused by the cleavage of a portion of cytoplasmic HuR. In this review, we describe the roles of HuR during myogenesis, and the mechanisms regulating its cytoplasmic accumulation. This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import.

Original languageEnglish
Pages (from-to)1663-1667
Number of pages5
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1813
Issue number9
DOIs
Publication statusPublished - 1 Sep 2011

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Keywords

  • Caspase
  • HuR
  • Myogenesis
  • Myogenic regulatory factor
  • Transportin 2

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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