Human neutrophil elastase functions as a type III collagen “Collagenase”

James E. Gadek, Gerald A. Fells, Daniel G. Wright, Ronald Crystal

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Under physiologic conditions, human neutrophil elastase cleaves triple helical human type III collagen into specific fragments in a fashion similar to that of a typical “collagenase”. In contrast, elastase does not attack the triple helical portion of type I collagen. However, unlike a classic collagenase, which is a metalloenzyme, the action of elastase on type III collagen is prevented by serine protease inhibitors. These findings suggest that the concepts of “collagenases” and “elastases” must be broadened and that human neutrophil elastase is capable of mediating a broad range of connective tissue destruction.

Original languageEnglish
Pages (from-to)1815-1822
Number of pages8
JournalTopics in Catalysis
Volume95
Issue number4
DOIs
Publication statusPublished - 1 Jan 1980
Externally publishedYes

Fingerprint

Leukocyte Elastase
Collagen Type III
Pancreatic Elastase
Collagenases
Collagen
Serine Proteinase Inhibitors
Collagen Type I
Tissue

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Human neutrophil elastase functions as a type III collagen “Collagenase”. / Gadek, James E.; Fells, Gerald A.; Wright, Daniel G.; Crystal, Ronald.

In: Topics in Catalysis, Vol. 95, No. 4, 01.01.1980, p. 1815-1822.

Research output: Contribution to journalArticle

Gadek, James E. ; Fells, Gerald A. ; Wright, Daniel G. ; Crystal, Ronald. / Human neutrophil elastase functions as a type III collagen “Collagenase”. In: Topics in Catalysis. 1980 ; Vol. 95, No. 4. pp. 1815-1822.
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