Human immunodeficiency virus type 1 (hiv-1) non-b subtypes are similar to hiv-1 subtype b in that coreceptor specificity is a determinant of cytopathicity in human lymphoid tissue infected ex vivo

N. Malkevich, C. Womack, P. Pandya, Jean-Charles B. Grivel, A. S. Fauci, L. Margolis

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Abstract

We sought to determine the relationship between virus-mediated CD4+ T-lymphocyte cytopathicity and viral coreceptor preference among various human immunodeficiency virus type 1 (HIV-1) subtypes in an ex vivo-infected human lymphoid tissue model. Our data show that all R5 HIV-1 infections resulted in mild depletion of CD4+ T lymphocytes, whereas all X4 HIV-1 infections caused severe depletion of CD4+ T lymphocytes regardless of their subtype origin. Thus, at least for the viruses within subtypes A, B, C, and E that were tested, coreceptor specificity is a critical factor that determines the ability of HIV-1 to deplete CD4+ T cells in human lymphoid tissue infected ex vivo.

Original languageEnglish
Pages (from-to)10520-10522
Number of pages3
JournalJournal of Virology
Volume75
Issue number21
DOIs
Publication statusPublished - 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Virology

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