Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue

Jean Charles Grivel, Michael L. Penn, Daniel A. Eckstein, Birgit Schramm, Roberto F. Speck, Nancy W. Abbey, Brian Herndier, Leonid Margolis, Mark A. Goldsmith

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Abstract

The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4+ T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor- expressing CD4+ lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.

Original languageEnglish
Pages (from-to)5347-5351
Number of pages5
JournalJournal of Virology
Volume74
Issue number11
DOIs
Publication statusPublished - 5 Jun 2000

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Grivel, J. C., Penn, M. L., Eckstein, D. A., Schramm, B., Speck, R. F., Abbey, N. W., Herndier, B., Margolis, L., & Goldsmith, M. A. (2000). Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue. Journal of Virology, 74(11), 5347-5351. https://doi.org/10.1128/JVI.74.11.5347-5351.2000