Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue

Jean-Charles B. Grivel, Michael L. Penn, Daniel A. Eckstein, Birgit Schramm, Roberto F. Speck, Nancy W. Abbey, Brian Herndier, Leonid Margolis, Mark A. Goldsmith

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4+ T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor- expressing CD4+ lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.

Original languageEnglish
Pages (from-to)5347-5351
Number of pages5
JournalJournal of Virology
Volume74
Issue number11
DOIs
Publication statusPublished - 2000
Externally publishedYes

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Tropism
Lymphoid Tissue
HIV-1
Lymphocytes
T-Lymphocytes
Macrophages

ASJC Scopus subject areas

  • Immunology

Cite this

Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue. / Grivel, Jean-Charles B.; Penn, Michael L.; Eckstein, Daniel A.; Schramm, Birgit; Speck, Roberto F.; Abbey, Nancy W.; Herndier, Brian; Margolis, Leonid; Goldsmith, Mark A.

In: Journal of Virology, Vol. 74, No. 11, 2000, p. 5347-5351.

Research output: Contribution to journalArticle

Grivel, J-CB, Penn, ML, Eckstein, DA, Schramm, B, Speck, RF, Abbey, NW, Herndier, B, Margolis, L & Goldsmith, MA 2000, 'Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue', Journal of Virology, vol. 74, no. 11, pp. 5347-5351. https://doi.org/10.1128/JVI.74.11.5347-5351.2000
Grivel, Jean-Charles B. ; Penn, Michael L. ; Eckstein, Daniel A. ; Schramm, Birgit ; Speck, Roberto F. ; Abbey, Nancy W. ; Herndier, Brian ; Margolis, Leonid ; Goldsmith, Mark A. / Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue. In: Journal of Virology. 2000 ; Vol. 74, No. 11. pp. 5347-5351.
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