Hsp-72, a candidate prognostic indicator of heatstroke

Mohammed Dehbi, Engin Baturcam, Abdelmoneim Eldali, Maqbool Ahmed, Aaron Kwaasi, Muhammad Azhar Chishti, Abderrezak Bouchama

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Exposure of rats to environmental heat enhances the expression of heat shock protein-72 (Hsp-72) in most of their organs proportionally to heat stress severity. Pre-induction or over-expression of Hsp-72 prevents organ damage and lethality, suggesting that heat shock proteins (Hsps) may have a pathogenic role in this condition. We investigated the expression profile of Hsps in baboons subjected to environmental heat stress until the core temperature attained 42.5°C (moderate heatstroke) or occurrence of hypotension associated with core temperature ≥ 43.5°C (severe heatstroke). Western blot analysis demonstrated a differential induction of Hsp-72 among organs of heat-stressed animals with the highest induction in the liver and the lowest in lung. Hsp-60 and Hsc-70 expression was similar between control and heat-stressed animals. ELISA studies indicated a marked release of Hsp-72 into the circulation of baboons with severe heatstroke with a peak at 24 h post-heatstroke onset and remained sustained up to 72 h. Hsp-72 release was not associated with core temperature or systolic blood pressure, but correlated with markers of liver, myocardium, and skeletal muscle tissue necrosis. Non-survivors displayed significantly higher Hsp-72 levels than survivors. No Hsp-60 was detected in the circulation. These findings add further evidence that increased expression of Hsp-72 may be an important component of the host response to severe heatstroke. They also suggest that extracellular Hsp-72 is a marker of multiple organs tissue damage. Whether extracellular Hsp-72 plays a role in the host immune response to heat stress merits further studies.

Original languageEnglish
Pages (from-to)593-603
Number of pages11
JournalCell Stress and Chaperones
Issue number5
Publication statusPublished - 1 Sep 2010



  • Baboon
  • Heat shock proteins
  • Heat stress
  • Heatstroke
  • Hyperthermia
  • Multiple organ dysfunction syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Dehbi, M., Baturcam, E., Eldali, A., Ahmed, M., Kwaasi, A., Chishti, M. A., & Bouchama, A. (2010). Hsp-72, a candidate prognostic indicator of heatstroke. Cell Stress and Chaperones, 15(5), 593-603. https://doi.org/10.1007/s12192-010-0172-3