How to make a good egg!. The need for remodeling of oocyte Ca2+ signaling to mediate the egg-to-embryo transition

Nancy Nader, Rashmi P. Kulkarni, Maya Dib, Khaled Machaca

Research output: Contribution to journalArticle

19 Citations (Scopus)


The egg-to-embryo transition marks the initiation of multicellular organismal development and is mediated by a specialized Ca2+ transient at fertilization. This explosive Ca2+ signal has captured the interest and imagination of scientists for many decades, given its cataclysmic nature and necessity for the egg-to-embryo transition. Learning how the egg acquires the competency to generate this Ca2+ transient at fertilization is essential to our understanding of the mechanisms controlling egg and the transition to embryogenesis. In this review we discuss our current knowledge of how Ca2+ signaling pathways remodel during oocyte maturation in preparation for fertilization with a special emphasis on the frog oocyte as additional reviews in this issue will touch on this in other species.

Original languageEnglish
Pages (from-to)41-54
Number of pages14
JournalCell Calcium
Issue number1
Publication statusPublished - 2013



  • Calcium
  • Egg
  • Egg-to-embryo transition
  • Endoplasmic reticulum
  • Fertilization
  • IP3 receptor
  • Oocyte
  • Oocyte maturation
  • Orai1
  • PMCA
  • Remodeling
  • STIM1

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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