How "Blind" Are Double-Blind Studies?

Jürgen Margraf, Anke Ehlers, Walton T. Roth, Duncan B. Clark, Javaid Sheikh, W. Stewart Agras, C. Barr Taylor

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Psychopharmacological studies usually attempt to eliminate "nonspecific" influences on outcome by double-blind designs. In a randomized, double-blind comparison of alprazolam, imipramine, and placebo, the great majority of panic disorder patients (N = 59) and their physicians were able to rate accurately whether active drug or placebo had been given. Moreover, physicians could distinguish between the two types of active drugs. Inasmuch as correct rating was possible halfway through treatment, concerns about the internal validity of the double-blind strategy arise.

Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalJournal of Consulting and Clinical Psychology
Volume59
Issue number1
Publication statusPublished - Feb 1991
Externally publishedYes

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Double-Blind Method
Placebos
Alprazolam
Physicians
Imipramine
Panic Disorder
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Margraf, J., Ehlers, A., Roth, W. T., Clark, D. B., Sheikh, J., Agras, W. S., & Taylor, C. B. (1991). How "Blind" Are Double-Blind Studies? Journal of Consulting and Clinical Psychology, 59(1), 184-187.

How "Blind" Are Double-Blind Studies? / Margraf, Jürgen; Ehlers, Anke; Roth, Walton T.; Clark, Duncan B.; Sheikh, Javaid; Agras, W. Stewart; Taylor, C. Barr.

In: Journal of Consulting and Clinical Psychology, Vol. 59, No. 1, 02.1991, p. 184-187.

Research output: Contribution to journalArticle

Margraf, J, Ehlers, A, Roth, WT, Clark, DB, Sheikh, J, Agras, WS & Taylor, CB 1991, 'How "Blind" Are Double-Blind Studies?', Journal of Consulting and Clinical Psychology, vol. 59, no. 1, pp. 184-187.
Margraf J, Ehlers A, Roth WT, Clark DB, Sheikh J, Agras WS et al. How "Blind" Are Double-Blind Studies? Journal of Consulting and Clinical Psychology. 1991 Feb;59(1):184-187.
Margraf, Jürgen ; Ehlers, Anke ; Roth, Walton T. ; Clark, Duncan B. ; Sheikh, Javaid ; Agras, W. Stewart ; Taylor, C. Barr. / How "Blind" Are Double-Blind Studies?. In: Journal of Consulting and Clinical Psychology. 1991 ; Vol. 59, No. 1. pp. 184-187.
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