Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with staphylococcus aureus infections

Romain Banchereau, Alejandro Jordan-Villegas, Monica Ardura, Asuncion Mejias, Nicole Baldwin, Hui Xu, Elizabeth Saye, Jose Rossello-Urgell, Phuong Nguyen, Derek Blankenship, Clarence B. Creech, Virginia Pascual, Jacques Banchereau, Damien J. Chaussabel, Octavio Ramilo

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Staphylococcus aureus infections are associated with diverse clinical manifestations leading to significant morbidity and mortality. To define the role of the host response in the clinical manifestations of the disease, we characterized whole blood transcriptional profiles of children hospitalized with community-acquired S. aureus infection and phenotyped the bacterial strains isolated. The overall transcriptional response to S. aureus infection was characterized by over-expression of innate immunity and hematopoiesis related genes and under-expression of genes related to adaptive immunity. We assessed individual profiles using modular fingerprints combined with the molecular distance to health (MDTH), a numerical score of transcriptional perturbation as compared to healthy controls. We observed significant heterogeneity in the host signatures and MDTH, as they were influenced by the type of clinical presentation, the extent of bacterial dissemination, and time of blood sampling in the course of the infection, but not by the bacterial isolate. System analysis approaches provide a new understanding of disease pathogenesis and the relation/interaction between host response and clinical disease manifestations.

Original languageEnglish
Article numbere34390
JournalPLoS One
Volume7
Issue number4
DOIs
Publication statusPublished - 4 Apr 2012
Externally publishedYes

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Staphylococcus aureus
Bacterial Infections
Blood
Genes
Infection
Health
infection
Hospitalized Child
Hematopoiesis
Dermatoglyphics
Adaptive Immunity
Systems Analysis
Innate Immunity
hematopoiesis
systems analysis
blood sampling
Systems analysis
Sampling
Morbidity
morbidity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with staphylococcus aureus infections. / Banchereau, Romain; Jordan-Villegas, Alejandro; Ardura, Monica; Mejias, Asuncion; Baldwin, Nicole; Xu, Hui; Saye, Elizabeth; Rossello-Urgell, Jose; Nguyen, Phuong; Blankenship, Derek; Creech, Clarence B.; Pascual, Virginia; Banchereau, Jacques; Chaussabel, Damien J.; Ramilo, Octavio.

In: PLoS One, Vol. 7, No. 4, e34390, 04.04.2012.

Research output: Contribution to journalArticle

Banchereau, R, Jordan-Villegas, A, Ardura, M, Mejias, A, Baldwin, N, Xu, H, Saye, E, Rossello-Urgell, J, Nguyen, P, Blankenship, D, Creech, CB, Pascual, V, Banchereau, J, Chaussabel, DJ & Ramilo, O 2012, 'Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with staphylococcus aureus infections', PLoS One, vol. 7, no. 4, e34390. https://doi.org/10.1371/journal.pone.0034390
Banchereau, Romain ; Jordan-Villegas, Alejandro ; Ardura, Monica ; Mejias, Asuncion ; Baldwin, Nicole ; Xu, Hui ; Saye, Elizabeth ; Rossello-Urgell, Jose ; Nguyen, Phuong ; Blankenship, Derek ; Creech, Clarence B. ; Pascual, Virginia ; Banchereau, Jacques ; Chaussabel, Damien J. ; Ramilo, Octavio. / Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with staphylococcus aureus infections. In: PLoS One. 2012 ; Vol. 7, No. 4.
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