HLA Class II genes in soybean epidemic asthma patients

Joan B. Soriano, Guadalupe Ercilla, Jordi Sunyer, Francisco X. Real, Conxi Lázaro, María J. Rodrigo, Xavier P. Estivill, Josep Roca, Robert Rodríguez-Roisín, Ferran Morell, Josep M. Antó

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

From 1981 to 1987, 26 outbreaks of asthma caused by the inhalation of soybean dust, affecting a total of 688 individuals, were detected in Barcelona, Spain. Because only a small proportion of asthmatic individuals living in Barcelona expressed the epidemic phenotype, it is hypothesized that a genetically determined human leukocyte antigen (HLA) Class II factor could have played a role in the susceptible individuals. Accordingly, we studied the distribution of both HLA-DR and HLA-DQ in soybean epidemic asthmatic patients. An analysis of the HLA-DR and HLA-DQ genes for genetic polymorphisms of the β1 chain was done with the polymerase chain reaction (PCR) in 78 soybean epidemic asthma patients, and the findings were compared with those for 67 nonepidemic asthmatic individuals and 168 individuals from the general population. An allelic disequilibrium could be established; the risk of epidemic asthma was particularly associated with the DRB1*13 gene (p value corrected for multiple comparisons < 0.02). The association observed for the DRB1*13 gene was stronger in individuals in the lowest tertile for total IgE, with an estimated risk with a 95% confidence interval (CI), of 14.5 (1.6 to 130.8). The combination of two genes from among the DRB1 *05- 05, DRB1*05-06, and DRB1 *06-06 genes was present in epidemic asthmatic subjects only. No association with an HLA-DQB1 allele could be observed. Genetic predisposition could contribute to the response of some asthmatic patients to exposure to soybean dust, having led to their being affected during the epidemics of asthma in Barcelona.

Original languageEnglish
Pages (from-to)1394-1398
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume156
Issue number5
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

MHC Class II Genes
HLA Antigens
Soybeans
Asthma
Genes
Dust
Genetic Polymorphisms
Genetic Predisposition to Disease
Spain
Immunoglobulin E
Inhalation
Disease Outbreaks
Alleles
Confidence Intervals
Phenotype
Polymerase Chain Reaction
Population

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Soriano, J. B., Ercilla, G., Sunyer, J., Real, F. X., Lázaro, C., Rodrigo, M. J., ... Antó, J. M. (1997). HLA Class II genes in soybean epidemic asthma patients. American Journal of Respiratory and Critical Care Medicine, 156(5), 1394-1398.

HLA Class II genes in soybean epidemic asthma patients. / Soriano, Joan B.; Ercilla, Guadalupe; Sunyer, Jordi; Real, Francisco X.; Lázaro, Conxi; Rodrigo, María J.; Estivill, Xavier P.; Roca, Josep; Rodríguez-Roisín, Robert; Morell, Ferran; Antó, Josep M.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 156, No. 5, 1997, p. 1394-1398.

Research output: Contribution to journalArticle

Soriano, JB, Ercilla, G, Sunyer, J, Real, FX, Lázaro, C, Rodrigo, MJ, Estivill, XP, Roca, J, Rodríguez-Roisín, R, Morell, F & Antó, JM 1997, 'HLA Class II genes in soybean epidemic asthma patients', American Journal of Respiratory and Critical Care Medicine, vol. 156, no. 5, pp. 1394-1398.
Soriano JB, Ercilla G, Sunyer J, Real FX, Lázaro C, Rodrigo MJ et al. HLA Class II genes in soybean epidemic asthma patients. American Journal of Respiratory and Critical Care Medicine. 1997;156(5):1394-1398.
Soriano, Joan B. ; Ercilla, Guadalupe ; Sunyer, Jordi ; Real, Francisco X. ; Lázaro, Conxi ; Rodrigo, María J. ; Estivill, Xavier P. ; Roca, Josep ; Rodríguez-Roisín, Robert ; Morell, Ferran ; Antó, Josep M. / HLA Class II genes in soybean epidemic asthma patients. In: American Journal of Respiratory and Critical Care Medicine. 1997 ; Vol. 156, No. 5. pp. 1394-1398.
@article{b30548d7d0d34210b00a02c9eb357887,
title = "HLA Class II genes in soybean epidemic asthma patients",
abstract = "From 1981 to 1987, 26 outbreaks of asthma caused by the inhalation of soybean dust, affecting a total of 688 individuals, were detected in Barcelona, Spain. Because only a small proportion of asthmatic individuals living in Barcelona expressed the epidemic phenotype, it is hypothesized that a genetically determined human leukocyte antigen (HLA) Class II factor could have played a role in the susceptible individuals. Accordingly, we studied the distribution of both HLA-DR and HLA-DQ in soybean epidemic asthmatic patients. An analysis of the HLA-DR and HLA-DQ genes for genetic polymorphisms of the β1 chain was done with the polymerase chain reaction (PCR) in 78 soybean epidemic asthma patients, and the findings were compared with those for 67 nonepidemic asthmatic individuals and 168 individuals from the general population. An allelic disequilibrium could be established; the risk of epidemic asthma was particularly associated with the DRB1*13 gene (p value corrected for multiple comparisons < 0.02). The association observed for the DRB1*13 gene was stronger in individuals in the lowest tertile for total IgE, with an estimated risk with a 95{\%} confidence interval (CI), of 14.5 (1.6 to 130.8). The combination of two genes from among the DRB1 *05- 05, DRB1*05-06, and DRB1 *06-06 genes was present in epidemic asthmatic subjects only. No association with an HLA-DQB1 allele could be observed. Genetic predisposition could contribute to the response of some asthmatic patients to exposure to soybean dust, having led to their being affected during the epidemics of asthma in Barcelona.",
author = "Soriano, {Joan B.} and Guadalupe Ercilla and Jordi Sunyer and Real, {Francisco X.} and Conxi L{\'a}zaro and Rodrigo, {Mar{\'i}a J.} and Estivill, {Xavier P.} and Josep Roca and Robert Rodr{\'i}guez-Rois{\'i}n and Ferran Morell and Ant{\'o}, {Josep M.}",
year = "1997",
language = "English",
volume = "156",
pages = "1394--1398",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "5",

}

TY - JOUR

T1 - HLA Class II genes in soybean epidemic asthma patients

AU - Soriano, Joan B.

AU - Ercilla, Guadalupe

AU - Sunyer, Jordi

AU - Real, Francisco X.

AU - Lázaro, Conxi

AU - Rodrigo, María J.

AU - Estivill, Xavier P.

AU - Roca, Josep

AU - Rodríguez-Roisín, Robert

AU - Morell, Ferran

AU - Antó, Josep M.

PY - 1997

Y1 - 1997

N2 - From 1981 to 1987, 26 outbreaks of asthma caused by the inhalation of soybean dust, affecting a total of 688 individuals, were detected in Barcelona, Spain. Because only a small proportion of asthmatic individuals living in Barcelona expressed the epidemic phenotype, it is hypothesized that a genetically determined human leukocyte antigen (HLA) Class II factor could have played a role in the susceptible individuals. Accordingly, we studied the distribution of both HLA-DR and HLA-DQ in soybean epidemic asthmatic patients. An analysis of the HLA-DR and HLA-DQ genes for genetic polymorphisms of the β1 chain was done with the polymerase chain reaction (PCR) in 78 soybean epidemic asthma patients, and the findings were compared with those for 67 nonepidemic asthmatic individuals and 168 individuals from the general population. An allelic disequilibrium could be established; the risk of epidemic asthma was particularly associated with the DRB1*13 gene (p value corrected for multiple comparisons < 0.02). The association observed for the DRB1*13 gene was stronger in individuals in the lowest tertile for total IgE, with an estimated risk with a 95% confidence interval (CI), of 14.5 (1.6 to 130.8). The combination of two genes from among the DRB1 *05- 05, DRB1*05-06, and DRB1 *06-06 genes was present in epidemic asthmatic subjects only. No association with an HLA-DQB1 allele could be observed. Genetic predisposition could contribute to the response of some asthmatic patients to exposure to soybean dust, having led to their being affected during the epidemics of asthma in Barcelona.

AB - From 1981 to 1987, 26 outbreaks of asthma caused by the inhalation of soybean dust, affecting a total of 688 individuals, were detected in Barcelona, Spain. Because only a small proportion of asthmatic individuals living in Barcelona expressed the epidemic phenotype, it is hypothesized that a genetically determined human leukocyte antigen (HLA) Class II factor could have played a role in the susceptible individuals. Accordingly, we studied the distribution of both HLA-DR and HLA-DQ in soybean epidemic asthmatic patients. An analysis of the HLA-DR and HLA-DQ genes for genetic polymorphisms of the β1 chain was done with the polymerase chain reaction (PCR) in 78 soybean epidemic asthma patients, and the findings were compared with those for 67 nonepidemic asthmatic individuals and 168 individuals from the general population. An allelic disequilibrium could be established; the risk of epidemic asthma was particularly associated with the DRB1*13 gene (p value corrected for multiple comparisons < 0.02). The association observed for the DRB1*13 gene was stronger in individuals in the lowest tertile for total IgE, with an estimated risk with a 95% confidence interval (CI), of 14.5 (1.6 to 130.8). The combination of two genes from among the DRB1 *05- 05, DRB1*05-06, and DRB1 *06-06 genes was present in epidemic asthmatic subjects only. No association with an HLA-DQB1 allele could be observed. Genetic predisposition could contribute to the response of some asthmatic patients to exposure to soybean dust, having led to their being affected during the epidemics of asthma in Barcelona.

UR - http://www.scopus.com/inward/record.url?scp=9844234804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9844234804&partnerID=8YFLogxK

M3 - Article

VL - 156

SP - 1394

EP - 1398

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 5

ER -