HIV-1 molecular epidemiology evidence and transmission patterns in the Middle East and North Africa

Ghina Mumtaz, Nahla Hilmi, Francisca Ayodeji Akala, Iris Semini, Gabriele Riedner, David Wilson, Laith Aburaddad

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The distribution of HIV-1 subtypes in a population tracks the spread and evolution of the epidemic. This study is a systematic review of all available evidence on HIV-1 molecular epidemiology and subtype distribution in the Middle East and North Africa. Sources of data included Medline and various institutional documents and databases. In several countries, a diverse distribution of HIV-1 subtypes was observed principally reflecting travel-related exogenous exposures. A trend for a dominant HIV-1 subtype was observed in a few other settings and was often linked to HIV transmission within specific high-risk groups such as subtype A and CRF35-AD among injecting drug users and subtype C among commercial sex networks. Multiple exogenous introductions of HIV-1 variants seemed common to all countries, as observed from the high diversity in subtypes, or the high genetic divergence among any specific subtype even if predominant. In several countries though, epidemic-type clustering of specific subtypes suggests established or nascent HIV epidemics among classic core risk groups for HIV infection. HIV prevention efforts in MENA must be prioritized for these high-risk groups.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalSexually Transmitted Infections
Volume87
Issue number2
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

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Northern Africa
Eastern Africa
Middle East
Molecular Epidemiology
HIV-1
HIV
Information Storage and Retrieval
Drug Users
HIV Infections
Cluster Analysis
Databases
Population

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

HIV-1 molecular epidemiology evidence and transmission patterns in the Middle East and North Africa. / Mumtaz, Ghina; Hilmi, Nahla; Akala, Francisca Ayodeji; Semini, Iris; Riedner, Gabriele; Wilson, David; Aburaddad, Laith.

In: Sexually Transmitted Infections, Vol. 87, No. 2, 03.2011, p. 101-106.

Research output: Contribution to journalArticle

Mumtaz, Ghina ; Hilmi, Nahla ; Akala, Francisca Ayodeji ; Semini, Iris ; Riedner, Gabriele ; Wilson, David ; Aburaddad, Laith. / HIV-1 molecular epidemiology evidence and transmission patterns in the Middle East and North Africa. In: Sexually Transmitted Infections. 2011 ; Vol. 87, No. 2. pp. 101-106.
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