HIV-1 Imposes Rigidity on Blood and Semen Cytokine Networks

Andrea Lisco, Andrea Introini, Arshi Munawwar, Christophe Vanpouille, Jean-Charles B. Grivel, Paul Blank, Sarman Singh, Leonid Margolis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Problem: Although it is established that the levels of individual cytokines are altered by HIV-1 infection, the changes in cytokine interrelations that organize them into networks have been poorly studied. Here, we evaluated these networks in HIV-infected and HIV-uninfected individuals in fluid compartments that are critical for HIV-1 pathogenesis and transmission, namely blood and semen. Method of Study: In samples collected from therapy-naïve HIV-1-infected and HIV-1-uninfected individuals, we measured HIV-1-load, CD4 cell count, and levels of 21 cytokines using a multiplex bead assay. Results: Cytokine networks in blood and semen were different for HIV-1-infected and HIV-1-uninfected individuals. In both compartments of HIV-1-infected individuals, the cytokine networks were more interlocked than in controls: HIV-1 infection resulted in the establishment of new correlations and in the strengthening of pre-existing correlations between different cytokines. In blood and semen of HIV-infected patients, there were, respectively, 68 and 72 statistically significant correlations between cytokines, while in uninfected individuals, there were 18 and 21 such correlations. Conclusion: HIV-1 infection reorganizes the cytokine networks, establishing new strong correlations between various cytokines and thus imposes a high rigidity on the cytokine network. This rigidity may reflect the impairment of the ability of the immune system to respond to microbial challenges.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume68
Issue number6
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Fingerprint

Semen
HIV-1
Cytokines
HIV Infections
HIV
CD4 Lymphocyte Count
Immune System

Keywords

  • Cytokines
  • HIV-1
  • Network
  • Semen

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Lisco, A., Introini, A., Munawwar, A., Vanpouille, C., Grivel, J-C. B., Blank, P., ... Margolis, L. (2012). HIV-1 Imposes Rigidity on Blood and Semen Cytokine Networks. American Journal of Reproductive Immunology, 68(6), 515-521. https://doi.org/10.1111/aji.12015

HIV-1 Imposes Rigidity on Blood and Semen Cytokine Networks. / Lisco, Andrea; Introini, Andrea; Munawwar, Arshi; Vanpouille, Christophe; Grivel, Jean-Charles B.; Blank, Paul; Singh, Sarman; Margolis, Leonid.

In: American Journal of Reproductive Immunology, Vol. 68, No. 6, 12.2012, p. 515-521.

Research output: Contribution to journalArticle

Lisco, A, Introini, A, Munawwar, A, Vanpouille, C, Grivel, J-CB, Blank, P, Singh, S & Margolis, L 2012, 'HIV-1 Imposes Rigidity on Blood and Semen Cytokine Networks', American Journal of Reproductive Immunology, vol. 68, no. 6, pp. 515-521. https://doi.org/10.1111/aji.12015
Lisco, Andrea ; Introini, Andrea ; Munawwar, Arshi ; Vanpouille, Christophe ; Grivel, Jean-Charles B. ; Blank, Paul ; Singh, Sarman ; Margolis, Leonid. / HIV-1 Imposes Rigidity on Blood and Semen Cytokine Networks. In: American Journal of Reproductive Immunology. 2012 ; Vol. 68, No. 6. pp. 515-521.
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