Histone variants and melanoma: facts and hypotheses

Nikifor K. Konstantinov, Constance J. Ulff-Møller, Stefan Dimitrov

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Melanoma is the most aggressive form of skin cancer with rising incidence and morbidity. Despite advances in treatment, the 10-yr survival for patients with metastatic disease is less than 10%. During the past few years, ongoing research on different epigenomic aberrations in melanoma has catalyzed better understanding of its pathogenesis and identification of new therapeutics. In our review, we will focus on the role of histone variants, key epigenetic players in melanoma initiation and progression. Specifically, incorporation of histone variants enables additional layers of chromatin structure, and here, we will describe how alterations in this epigenetic behavior impact melanoma.

Original languageEnglish
Pages (from-to)426-433
Number of pages8
JournalPigment Cell and Melanoma Research
Volume29
Issue number4
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

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Keywords

  • epigenetics
  • H3.3
  • histone variants
  • macroH2A
  • melanoma

ASJC Scopus subject areas

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

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