Highly efficient and chemoselective peptide ubiquitylation

K. S. Ajish Kumar, Mahmood Haj-Yahya, Diana Olschewski, Hilal A. Lashuel, Ashraf Brik

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Loving kiss of death: A highly efficient and chemoselective method for ubiquitylation of peptides using δ-mercaptolysine to assist isopeptide formation between the ε-NH2 of the lysine residue and the activated C-terminal glycine of ubiquitin (Ub) is presented.

Original languageEnglish
Pages (from-to)8090-8094
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number43
DOIs
Publication statusPublished - 12 Oct 2009
Externally publishedYes

Fingerprint

Ubiquitination
Ubiquitin
Glycine
Peptides
Lysine
Amino acids

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Ajish Kumar, K. S., Haj-Yahya, M., Olschewski, D., Lashuel, H. A., & Brik, A. (2009). Highly efficient and chemoselective peptide ubiquitylation. Angewandte Chemie - International Edition, 48(43), 8090-8094. https://doi.org/10.1002/anie.200902936

Highly efficient and chemoselective peptide ubiquitylation. / Ajish Kumar, K. S.; Haj-Yahya, Mahmood; Olschewski, Diana; Lashuel, Hilal A.; Brik, Ashraf.

In: Angewandte Chemie - International Edition, Vol. 48, No. 43, 12.10.2009, p. 8090-8094.

Research output: Contribution to journalArticle

Ajish Kumar, KS, Haj-Yahya, M, Olschewski, D, Lashuel, HA & Brik, A 2009, 'Highly efficient and chemoselective peptide ubiquitylation', Angewandte Chemie - International Edition, vol. 48, no. 43, pp. 8090-8094. https://doi.org/10.1002/anie.200902936
Ajish Kumar KS, Haj-Yahya M, Olschewski D, Lashuel HA, Brik A. Highly efficient and chemoselective peptide ubiquitylation. Angewandte Chemie - International Edition. 2009 Oct 12;48(43):8090-8094. https://doi.org/10.1002/anie.200902936
Ajish Kumar, K. S. ; Haj-Yahya, Mahmood ; Olschewski, Diana ; Lashuel, Hilal A. ; Brik, Ashraf. / Highly efficient and chemoselective peptide ubiquitylation. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 43. pp. 8090-8094.
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