Highly efficient and chemoselective peptide ubiquitylation

K. S. Ajish Kumar, Mahmood Haj-Yahya, Diana Olschewski, Hilal A. Lashuel, Ashraf Brik

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172 Citations (Scopus)


Loving kiss of death: A highly efficient and chemoselective method for ubiquitylation of peptides using δ-mercaptolysine to assist isopeptide formation between the ε-NH2 of the lysine residue and the activated C-terminal glycine of ubiquitin (Ub) is presented.

Original languageEnglish
Pages (from-to)8090-8094
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number43
Publication statusPublished - 12 Oct 2009


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Ajish Kumar, K. S., Haj-Yahya, M., Olschewski, D., Lashuel, H. A., & Brik, A. (2009). Highly efficient and chemoselective peptide ubiquitylation. Angewandte Chemie - International Edition, 48(43), 8090-8094. https://doi.org/10.1002/anie.200902936