Heritability of cardiac size

An echocardiographic and electrocardiographic study of monozygotic and dizygotic twins

T. D. Adams, F. G. Yanowitz, A. G. Fisher, J. D. Ridges, A. G. Nelson, A. D. Hagan, R. R. Williams, Steven Hunt

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Because of the uncertainty as to the extent to which cardiac size is determined by exercise training vs genetic endowment, this study investigated familial (genetic plus common family environment) vs nonfamilial influences on cardiac size. College-age monozygotic twins (group 1, 31 sets), dizygotic twins (group 2, 10 sets), siblings of like sex (group 3, six sets), and nonrelated subjects (group 4, 15 sets) underwent echocardiographic and electrocardiographic tests, measurement of maximum oxygen uptake (V̇O2 max), and evaluation of pulmonary and body composition; mean intrapair differences of the four groups were compared. Mean intrapair differences in cardiac size varied as much for subjects in group 1 as for those in groups 2 and 3. However, subjects in groups 1, 2, and 3 had less variation (p < .05) than those in group 4. After the initial testing, 14 pairs of monozygotic twins, five sets of dizygotic twins, and six sets of siblings underwent 14 weeks of exercise training (both members participated) and all tests were repeated. After exercise training, subjects in group 1 still had as much intrapair variability in cardiac size as those in groups 2 and 3. The data suggest cultural familial influences are more important in determining cardiac size than nonfamilial influences or even genetic influences alone.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalCirculation
Volume71
Issue number1
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Dizygotic Twins
Monozygotic Twins
Exercise
Siblings
Financial Management
Body Composition
Uncertainty
Oxygen
Lung

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Adams, T. D., Yanowitz, F. G., Fisher, A. G., Ridges, J. D., Nelson, A. G., Hagan, A. D., ... Hunt, S. (1985). Heritability of cardiac size: An echocardiographic and electrocardiographic study of monozygotic and dizygotic twins. Circulation, 71(1), 39-44.

Heritability of cardiac size : An echocardiographic and electrocardiographic study of monozygotic and dizygotic twins. / Adams, T. D.; Yanowitz, F. G.; Fisher, A. G.; Ridges, J. D.; Nelson, A. G.; Hagan, A. D.; Williams, R. R.; Hunt, Steven.

In: Circulation, Vol. 71, No. 1, 1985, p. 39-44.

Research output: Contribution to journalArticle

Adams, TD, Yanowitz, FG, Fisher, AG, Ridges, JD, Nelson, AG, Hagan, AD, Williams, RR & Hunt, S 1985, 'Heritability of cardiac size: An echocardiographic and electrocardiographic study of monozygotic and dizygotic twins', Circulation, vol. 71, no. 1, pp. 39-44.
Adams TD, Yanowitz FG, Fisher AG, Ridges JD, Nelson AG, Hagan AD et al. Heritability of cardiac size: An echocardiographic and electrocardiographic study of monozygotic and dizygotic twins. Circulation. 1985;71(1):39-44.
Adams, T. D. ; Yanowitz, F. G. ; Fisher, A. G. ; Ridges, J. D. ; Nelson, A. G. ; Hagan, A. D. ; Williams, R. R. ; Hunt, Steven. / Heritability of cardiac size : An echocardiographic and electrocardiographic study of monozygotic and dizygotic twins. In: Circulation. 1985 ; Vol. 71, No. 1. pp. 39-44.
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