Heritability estimates of pulmonary function

A. J. Ghio, R. O. Crapo, C. G. Elliott, T. D. Adams, Steven Hunt, R. L. Jensen, A. G. Fisher, G. H. Afman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

To test the hypothesis that there is a genetic control of pulmonary function parameters independent of that influencing height, we evaluated 74 pairs of asymptomatic, nonsmoking twins. FVC, FEV1, FEF25-75%, TLCsb, RVsb, Dsb, and D/VA were measured. Pulmonary function indices were adjusted for height using simple linear regression. Mean intrapair differences (unadjusted and adjusted for height) were compared using t tests of independent samples. Within pair, Holzinger's, and Falconer's heritability estimates were calculated using height-adjusted residual values. When total variances of a function parameter were statistically different between monozygotes and dizygotes, the among component heritability, estimate was calculated and used as the best indicator of heritability. Following adjustment for height, no measure of pulmonary function which satisfied the requirements of the analysis was found to be significantly heritable.

Original languageEnglish
Pages (from-to)743-746
Number of pages4
JournalChest
Volume96
Issue number4
Publication statusPublished - 1989
Externally publishedYes

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Lung
Linear Models

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ghio, A. J., Crapo, R. O., Elliott, C. G., Adams, T. D., Hunt, S., Jensen, R. L., ... Afman, G. H. (1989). Heritability estimates of pulmonary function. Chest, 96(4), 743-746.

Heritability estimates of pulmonary function. / Ghio, A. J.; Crapo, R. O.; Elliott, C. G.; Adams, T. D.; Hunt, Steven; Jensen, R. L.; Fisher, A. G.; Afman, G. H.

In: Chest, Vol. 96, No. 4, 1989, p. 743-746.

Research output: Contribution to journalArticle

Ghio, AJ, Crapo, RO, Elliott, CG, Adams, TD, Hunt, S, Jensen, RL, Fisher, AG & Afman, GH 1989, 'Heritability estimates of pulmonary function', Chest, vol. 96, no. 4, pp. 743-746.
Ghio AJ, Crapo RO, Elliott CG, Adams TD, Hunt S, Jensen RL et al. Heritability estimates of pulmonary function. Chest. 1989;96(4):743-746.
Ghio, A. J. ; Crapo, R. O. ; Elliott, C. G. ; Adams, T. D. ; Hunt, Steven ; Jensen, R. L. ; Fisher, A. G. ; Afman, G. H. / Heritability estimates of pulmonary function. In: Chest. 1989 ; Vol. 96, No. 4. pp. 743-746.
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