Heritability estimates of pulmonary function

A. J. Ghio, R. O. Crapo, C. G. Elliott, T. D. Adams, Steven Hunt, R. L. Jensen, A. G. Fisher, G. H. Afman

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To test the hypothesis that there is a genetic control of pulmonary function parameters independent of that influencing height, we evaluated 74 pairs of asymptomatic, nonsmoking twins. FVC, FEV1, FEF25-75%, TLCsb, RVsb, Dsb, and D/VA were measured. Pulmonary function indices were adjusted for height using simple linear regression. Mean intrapair differences (unadjusted and adjusted for height) were compared using t tests of independent samples. Within pair, Holzinger's, and Falconer's heritability estimates were calculated using height-adjusted residual values. When total variances of a function parameter were statistically different between monozygotes and dizygotes, the among component heritability, estimate was calculated and used as the best indicator of heritability. Following adjustment for height, no measure of pulmonary function which satisfied the requirements of the analysis was found to be significantly heritable.

Original languageEnglish
Pages (from-to)743-746
Number of pages4
Issue number4
Publication statusPublished - 1989
Externally publishedYes


ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ghio, A. J., Crapo, R. O., Elliott, C. G., Adams, T. D., Hunt, S., Jensen, R. L., Fisher, A. G., & Afman, G. H. (1989). Heritability estimates of pulmonary function. Chest, 96(4), 743-746.