Hereditary emphysema in the tight-skin mouse. Evaluation of pathogenesis

G. A. Rossi, G. W. Hunninghake, J. E. Gadek, S. V. Szapiel, O. Kawanami, V. J. Ferrans, Ronald Crystal

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Abstract

The tight-skin (Tsk/+) mouse is a genetically determined model characterized by alveolar enlargement and physiologic evidence of emphysema. Morphologic evaluation of the lungs of these animals demonstrated increased numbers of potential protease-secreting cells (alveolar macrophages and neutrophils) in the lower respiratory tract prior to development of the emphysematous lesions. Quantitation of the neutrophils in the lungs of these animals was carried out by bronchoalveolar lavage. In the Tsk/+ mice, neutrophils constituted 3.5 ± 2% of all inflammatory and immune effector cells present compared with 0.4 ± 0.1% in control (+/+) mice (p < 0.01). The Tsk/+ animals had no evidence of infection to explain the presence of the neutrophils and had normal proportions of lung T- and B-lymphocytes, suggesting that their lungs were immunologically normal. There was no evidence that the Tsk/+ mice have an antiprotease deficit; the capacity of serum of Tsk/+ mice to inhibit neutrophil elastase was no different from that of control +/+ animals. However, the fact that these animals have a persistent low level macrophage-neutrophil alveolitis prior to the development of the emphysematous lesion implies that the lung destruction may be associated, in part, with a chronic protease-antiprotease imbalance, similar to that hypothesized for human emphysema.

Original languageEnglish
Pages (from-to)850-855
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume129
Issue number5
Publication statusPublished - 19 Jul 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Rossi, G. A., Hunninghake, G. W., Gadek, J. E., Szapiel, S. V., Kawanami, O., Ferrans, V. J., & Crystal, R. (1984). Hereditary emphysema in the tight-skin mouse. Evaluation of pathogenesis. American Review of Respiratory Disease, 129(5), 850-855.