Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions

Sara Deola, Monica C. Panelli, Dragan Maric, Silvia Selleri, Natalia I. Dmitrieva, Ching Y. Voss, Harvey Klein, David Stroncek, Ena Wang, Francesco M. Marincola

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Abstract

CD8-expressing cytotoxic T cell (CTL) interactions with APCs and helper T cells determine their function and ability to survive. In this study, we describe a novel interaction independent of Ag presentation between activated CTLs and bystander CD19-expressing B lymphocytes. Ag-stimulated CTLs serially engage autologous B lymphocytes through CD27/CD70 contact that promotes their survival and proliferation. Moreover, these interactions induce the release of proinflammatory cytokines that follows two general patterns: 1) an epitope-dependent enhancement of cytokine release, and 2) a previously undiscovered coordinate release of cytokines independent of epitope exposure. The latter includes chemoattractants targeting activated T cells. As a result, activated T cells are attracted to B cells, which exert a "helper" role in lymphatic organs or in areas of inflammation. This observation provides a mechanistic explanation to previously reported experimental observations suggesting that B cells are required for T cell priming in vivo.

Original languageEnglish
Pages (from-to)1362-1372
Number of pages11
JournalJournal of Immunology
Volume180
Issue number3
Publication statusPublished - 1 Feb 2008
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Deola, S., Panelli, M. C., Maric, D., Selleri, S., Dmitrieva, N. I., Voss, C. Y., Klein, H., Stroncek, D., Wang, E., & Marincola, F. M. (2008). Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions. Journal of Immunology, 180(3), 1362-1372.