Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions

Sara Deola, Monica C. Panelli, Dragan Maric, Silvia Selleri, Natalia I. Dmitrieva, Ching Y. Voss, Harvey Klein, David Stroncek, Ena Wang, Francesco M. Marincola

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

CD8-expressing cytotoxic T cell (CTL) interactions with APCs and helper T cells determine their function and ability to survive. In this study, we describe a novel interaction independent of Ag presentation between activated CTLs and bystander CD19-expressing B lymphocytes. Ag-stimulated CTLs serially engage autologous B lymphocytes through CD27/CD70 contact that promotes their survival and proliferation. Moreover, these interactions induce the release of proinflammatory cytokines that follows two general patterns: 1) an epitope-dependent enhancement of cytokine release, and 2) a previously undiscovered coordinate release of cytokines independent of epitope exposure. The latter includes chemoattractants targeting activated T cells. As a result, activated T cells are attracted to B cells, which exert a "helper" role in lymphatic organs or in areas of inflammation. This observation provides a mechanistic explanation to previously reported experimental observations suggesting that B cells are required for T cell priming in vivo.

Original languageEnglish
Pages (from-to)1362-1372
Number of pages11
JournalJournal of Immunology
Volume180
Issue number3
Publication statusPublished - 1 Feb 2008
Externally publishedYes

Fingerprint

Antigen Presentation
Helper-Inducer T-Lymphocytes
Cell Survival
B-Lymphocytes
Cell Proliferation
T-Lymphocytes
Cytokines
Epitopes
Chemotactic Factors
Cell Communication
Inflammation

ASJC Scopus subject areas

  • Immunology

Cite this

Deola, S., Panelli, M. C., Maric, D., Selleri, S., Dmitrieva, N. I., Voss, C. Y., ... Marincola, F. M. (2008). Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions. Journal of Immunology, 180(3), 1362-1372.

Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions. / Deola, Sara; Panelli, Monica C.; Maric, Dragan; Selleri, Silvia; Dmitrieva, Natalia I.; Voss, Ching Y.; Klein, Harvey; Stroncek, David; Wang, Ena; Marincola, Francesco M.

In: Journal of Immunology, Vol. 180, No. 3, 01.02.2008, p. 1362-1372.

Research output: Contribution to journalArticle

Deola, S, Panelli, MC, Maric, D, Selleri, S, Dmitrieva, NI, Voss, CY, Klein, H, Stroncek, D, Wang, E & Marincola, FM 2008, 'Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions', Journal of Immunology, vol. 180, no. 3, pp. 1362-1372.
Deola, Sara ; Panelli, Monica C. ; Maric, Dragan ; Selleri, Silvia ; Dmitrieva, Natalia I. ; Voss, Ching Y. ; Klein, Harvey ; Stroncek, David ; Wang, Ena ; Marincola, Francesco M. / Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions. In: Journal of Immunology. 2008 ; Vol. 180, No. 3. pp. 1362-1372.
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