Abstract
DYRK1A is a protein kinase proposed to be involved in neurogenesis. Gene-targeting disruption of Dyrk1A in mice leads to decreased body and brain size, with no severe disturbance of behavior. In this study, the authors focused on the motor profile of Dyrk1A+/- mice. These mice presented impairment of neuromotor development with decreased activity, suggesting a physiological role of Dyrk1A in the maturation of the neuromotor system. In the adult, a marked hypoactivity and alteration of specific motor parameters were detected. These results are in agreement with the significant expression of Dyrk1A in structures related to motor function and support a role of Dyrk1A in the control of motor function.
| Original language | English |
|---|---|
| Pages (from-to) | 815-821 |
| Number of pages | 7 |
| Journal | Behavioral Neuroscience |
| Volume | 118 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Behavioral Neuroscience
- Clinical Psychology
Cite this
Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity. / Fotaki, V.; Martínez De Lagrán, M.; Estivill, Xavier P.; Arbonés, M.; Dierssen, M.
In: Behavioral Neuroscience, Vol. 118, No. 4, 08.2004, p. 815-821.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity
AU - Fotaki, V.
AU - Martínez De Lagrán, M.
AU - Estivill, Xavier P.
AU - Arbonés, M.
AU - Dierssen, M.
PY - 2004/8
Y1 - 2004/8
N2 - DYRK1A is a protein kinase proposed to be involved in neurogenesis. Gene-targeting disruption of Dyrk1A in mice leads to decreased body and brain size, with no severe disturbance of behavior. In this study, the authors focused on the motor profile of Dyrk1A+/- mice. These mice presented impairment of neuromotor development with decreased activity, suggesting a physiological role of Dyrk1A in the maturation of the neuromotor system. In the adult, a marked hypoactivity and alteration of specific motor parameters were detected. These results are in agreement with the significant expression of Dyrk1A in structures related to motor function and support a role of Dyrk1A in the control of motor function.
AB - DYRK1A is a protein kinase proposed to be involved in neurogenesis. Gene-targeting disruption of Dyrk1A in mice leads to decreased body and brain size, with no severe disturbance of behavior. In this study, the authors focused on the motor profile of Dyrk1A+/- mice. These mice presented impairment of neuromotor development with decreased activity, suggesting a physiological role of Dyrk1A in the maturation of the neuromotor system. In the adult, a marked hypoactivity and alteration of specific motor parameters were detected. These results are in agreement with the significant expression of Dyrk1A in structures related to motor function and support a role of Dyrk1A in the control of motor function.
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UR - http://www.scopus.com/inward/citedby.url?scp=3242816217&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.118.4.815
DO - 10.1037/0735-7044.118.4.815
M3 - Article
C2 - 15301607
AN - SCOPUS:3242816217
VL - 118
SP - 815
EP - 821
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 4
ER -