Gut microbiome production of short-chain fatty acids and obesity in children

Selvasankar Murugesan, Khemlal Nirmalkar, Carlos Hoyo-Vadillo, Matilde García-Espitia, Daniela Ramírez-Sánchez, Jaime García-Mena

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Obesity has been a worldwide multifactorial epidemic malady for the last 2 decades. Changes in gut microbiota composition and its metabolites — short-chain fatty acids (SCFAs) — have been associated with obesity. Recent evidence suggests that SCFAs made by the gut microbiota may regulate directly or indirectly physiological and pathological processes in relation to obesity. We review the influence of gut microbiota in energy, glucose, and lipid homeostasis control via their metabolites. Gut microbial disturbances in obese children may have a role in their metabolism. At first glance, excessive short-chain fatty acids produced by a particular gut microbiota represent an additional energy source, and should cause an imbalance in energy regulation, contributing to obesity. However, simultaneously, SCFA participates in glucose-stimulated insulin secretion from the pancreatic β-cells through interaction with the FFA2 and FFA3 receptors, and release of peptide hormones which control appetite. This apparent contradictory situation may indicate the involvement of additional particular bacteria or bacterial components or metabolites that may trigger regulatory cascades by interaction with some G-protein-coupled membrane receptors.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
DOIs
Publication statusAccepted/In press - 2 Dec 2017
Externally publishedYes

Fingerprint

Volatile Fatty Acids
Pediatric Obesity
Obesity
Physiological Phenomena
Glucose
Peptide Receptors
Appetite
Pathologic Processes
G-Protein-Coupled Receptors
Cell Communication
Homeostasis
Insulin
Bacteria
Lipids
Membranes
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Gut microbiome production of short-chain fatty acids and obesity in children. / Murugesan, Selvasankar; Nirmalkar, Khemlal; Hoyo-Vadillo, Carlos; García-Espitia, Matilde; Ramírez-Sánchez, Daniela; García-Mena, Jaime.

In: European Journal of Clinical Microbiology and Infectious Diseases, 02.12.2017, p. 1-5.

Research output: Contribution to journalArticle

Murugesan, Selvasankar ; Nirmalkar, Khemlal ; Hoyo-Vadillo, Carlos ; García-Espitia, Matilde ; Ramírez-Sánchez, Daniela ; García-Mena, Jaime. / Gut microbiome production of short-chain fatty acids and obesity in children. In: European Journal of Clinical Microbiology and Infectious Diseases. 2017 ; pp. 1-5.
@article{08616863bcea404da6dfeff9e8a3fab8,
title = "Gut microbiome production of short-chain fatty acids and obesity in children",
abstract = "Obesity has been a worldwide multifactorial epidemic malady for the last 2 decades. Changes in gut microbiota composition and its metabolites — short-chain fatty acids (SCFAs) — have been associated with obesity. Recent evidence suggests that SCFAs made by the gut microbiota may regulate directly or indirectly physiological and pathological processes in relation to obesity. We review the influence of gut microbiota in energy, glucose, and lipid homeostasis control via their metabolites. Gut microbial disturbances in obese children may have a role in their metabolism. At first glance, excessive short-chain fatty acids produced by a particular gut microbiota represent an additional energy source, and should cause an imbalance in energy regulation, contributing to obesity. However, simultaneously, SCFA participates in glucose-stimulated insulin secretion from the pancreatic β-cells through interaction with the FFA2 and FFA3 receptors, and release of peptide hormones which control appetite. This apparent contradictory situation may indicate the involvement of additional particular bacteria or bacterial components or metabolites that may trigger regulatory cascades by interaction with some G-protein-coupled membrane receptors.",
author = "Selvasankar Murugesan and Khemlal Nirmalkar and Carlos Hoyo-Vadillo and Matilde Garc{\'i}a-Espitia and Daniela Ram{\'i}rez-S{\'a}nchez and Jaime Garc{\'i}a-Mena",
year = "2017",
month = "12",
day = "2",
doi = "10.1007/s10096-017-3143-0",
language = "English",
pages = "1--5",
journal = "European Journal of Clinical Microbiology and Infectious Diseases",
issn = "0934-9723",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Gut microbiome production of short-chain fatty acids and obesity in children

AU - Murugesan, Selvasankar

AU - Nirmalkar, Khemlal

AU - Hoyo-Vadillo, Carlos

AU - García-Espitia, Matilde

AU - Ramírez-Sánchez, Daniela

AU - García-Mena, Jaime

PY - 2017/12/2

Y1 - 2017/12/2

N2 - Obesity has been a worldwide multifactorial epidemic malady for the last 2 decades. Changes in gut microbiota composition and its metabolites — short-chain fatty acids (SCFAs) — have been associated with obesity. Recent evidence suggests that SCFAs made by the gut microbiota may regulate directly or indirectly physiological and pathological processes in relation to obesity. We review the influence of gut microbiota in energy, glucose, and lipid homeostasis control via their metabolites. Gut microbial disturbances in obese children may have a role in their metabolism. At first glance, excessive short-chain fatty acids produced by a particular gut microbiota represent an additional energy source, and should cause an imbalance in energy regulation, contributing to obesity. However, simultaneously, SCFA participates in glucose-stimulated insulin secretion from the pancreatic β-cells through interaction with the FFA2 and FFA3 receptors, and release of peptide hormones which control appetite. This apparent contradictory situation may indicate the involvement of additional particular bacteria or bacterial components or metabolites that may trigger regulatory cascades by interaction with some G-protein-coupled membrane receptors.

AB - Obesity has been a worldwide multifactorial epidemic malady for the last 2 decades. Changes in gut microbiota composition and its metabolites — short-chain fatty acids (SCFAs) — have been associated with obesity. Recent evidence suggests that SCFAs made by the gut microbiota may regulate directly or indirectly physiological and pathological processes in relation to obesity. We review the influence of gut microbiota in energy, glucose, and lipid homeostasis control via their metabolites. Gut microbial disturbances in obese children may have a role in their metabolism. At first glance, excessive short-chain fatty acids produced by a particular gut microbiota represent an additional energy source, and should cause an imbalance in energy regulation, contributing to obesity. However, simultaneously, SCFA participates in glucose-stimulated insulin secretion from the pancreatic β-cells through interaction with the FFA2 and FFA3 receptors, and release of peptide hormones which control appetite. This apparent contradictory situation may indicate the involvement of additional particular bacteria or bacterial components or metabolites that may trigger regulatory cascades by interaction with some G-protein-coupled membrane receptors.

UR - http://www.scopus.com/inward/record.url?scp=85035783511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85035783511&partnerID=8YFLogxK

U2 - 10.1007/s10096-017-3143-0

DO - 10.1007/s10096-017-3143-0

M3 - Article

C2 - 29196878

AN - SCOPUS:85035783511

SP - 1

EP - 5

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

SN - 0934-9723

ER -