Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization

Upendar Reddy Gandra, Alessandro Sinopoli, Salvador Moncho Escriva, Manjula Nandakumar, Dragan B. Ninković, Snežana D. Zarić, Muhammad Sohail, Saeed Al-Meer, Edward Brothers, Nayef Mazloum, Mohammed Al-Hashimi, Hassan S. Bazzi

Research output: Contribution to journalArticle


Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization. Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent density functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells.

Original languageEnglish
JournalACS Applied Materials and Interfaces
Publication statusAccepted/In press - 1 Jan 2019



  • carbon monoxide (CO)
  • CO-releasing material (CORMat)
  • light-responsive
  • polymer conjugates
  • portable CO storage and CO release bandage

ASJC Scopus subject areas

  • Materials Science(all)

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