Granulocyte collagenase: selective digestion of type I relative to type III collagen

A. L. Horwitz, A. J. Hance, R. G. Crystal

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Abstract

Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume74
Issue number3
DOIs
Publication statusPublished - 1 Jan 1977

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