Granulocyte collagenase

selective digestion of type I relative to type III collagen

A. L. Horwitz, A. J. Hance, Ronald Crystal

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume74
Issue number3
DOIs
Publication statusPublished - 1 Jan 1977
Externally publishedYes

Fingerprint

Collagen Type III
Collagenases
Granulocytes
Digestion
Collagen
Alveolar Macrophages
Collagen Type I
Matrix Metalloproteinase 8
Rabbits
Connective Tissue
Proteolysis
Neutrophils
Leukocytes
Fibroblasts
Macrophages
Inflammation
Lung

ASJC Scopus subject areas

  • General

Cite this

Granulocyte collagenase : selective digestion of type I relative to type III collagen. / Horwitz, A. L.; Hance, A. J.; Crystal, Ronald.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 74, No. 3, 01.01.1977, p. 897-901.

Research output: Contribution to journalArticle

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